Honey for wound healing, ulcers, and burns; data supporting its use in clinical practice.
Honey for wound healing, ulcers, and burns; data supporting its use in clinical practice.
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DOI：
10.1100/tsw.2011.78
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发表时间：
2011-04-05
影响因子：
--
通讯作者：
Al-Ghamdi AA
中科院分区：
文献类型：
--
作者：
Al-Waili N;Salom K;Al-Ghamdi AA
未愈合的伤口、溃疡和烧伤的普遍存在对公共健康和经济造成了极大的影响。许多干预措施，包括新的药物和技术，正在被用来帮助实现显著的伤口愈合和消除感染。因此，寻找一种对愈合过程既有治疗效果又能杀灭微生物的干预措施是非常有价值的。蜂蜜是最近在现代医疗实践中引入的一种天然产品。蜂蜜的抗菌性能及其对伤口愈合的影响已经得到了深入的研究。实验室研究和临床试验表明，蜂蜜是一种有效的广谱抗菌剂。本文综述了支持天然蜂蜜在伤口愈合中的有效性及其消毒感染伤口的能力的数据。综述了不同地区采集的蜂蜜对皮肤创伤、皮肤和胃溃疡以及烧伤的治疗作用的研究，并对其作用机制进行了探讨。(溃疡和烧伤包括在内，作为挑战性伤口的一个例子。)数据显示，蜂蜜的伤口愈合特性包括刺激组织生长，促进上皮化，并最大限度地减少疤痕形成。这些影响归因于蜂蜜的酸度、过氧化氢含量、渗透作用、营养和抗氧化剂含量、免疫刺激以及未知化合物。前列腺素和一氧化氮在炎症、微生物死亡和愈合过程中发挥着重要作用。研究发现，蜂蜜可以降低前列腺素水平，升高一氧化氮终产物。这些特性可能有助于解释蜂蜜的一些生物学和治疗特性，特别是作为抗菌剂或伤口治疗剂。这里提供的数据表明，来自不同地区的蜂蜜对慢性伤口、溃疡和烧伤有相当大的治疗效果。这一结果鼓励在临床实践中使用蜂蜜作为一种自然和安全的伤口愈合剂。
The widespread existence of unhealed wounds, ulcers, and burns has a great impact on public health and economy. Many interventions, including new medications and technologies, are being used to help achieve significant wound healing and to eliminate infections. Therefore, to find an intervention that has both therapeutic effect on the healing process and the ability to kill microbes is of great value. Honey is a natural product that has been recently introduced in modern medical practice. Honey's antibacterial properties and its effects on wound healing have been thoroughly investigated. Laboratory studies and clinical trials have shown that honey is an effective broad-spectrum antibacterial agent. This paper reviews data that support the effectiveness of natural honey in wound healing and its ability to sterilize infected wounds. Studies on the therapeutic effects of honey collected in different geographical areas on skin wounds, skin and gastric ulcers, and burns are reviewed and mechanisms of action are discussed. (Ulcers and burns are included as an example of challenging wounds.) The data show that the wound healing properties of honey include stimulation of tissue growth, enhanced epithelialization, and minimized scar formation. These effects are ascribed to honey's acidity, hydrogen peroxide content, osmotic effect, nutritional and antioxidant contents, stimulation of immunity, and to unidentified compounds. Prostaglandins and nitric oxide play a major role in inflammation, microbial killing, and the healing process. Honey was found to lower prostaglandin levels and elevate nitric oxide end products. These properties might help to explain some biological and therapeutic properties of honey, particularly as an antibacterial agent or wound healer. The data presented here demonstrate that honeys from different geographical areas have considerable therapeutic effects on chronic wounds, ulcers, and burns. The results encourage the use of honey in clinical practice as a natural and safe wound healer.
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影响因子：
2.4
作者：
Al-Waili, NS;Boni, NS
通讯作者：
Boni, NS
影响因子：
3.6
作者：
Bennett, LL;Rosenblum, RS;Nanney, LB
通讯作者：
Nanney, LB
影响因子：
0.8
作者：
Baghel, P. S.;Shukla, S.;Randa, R.
通讯作者：
Randa, R.
影响因子：
2
作者：
Ayyildiz, Ali;Akguel, K. Turgay;Germiyanoglu, Cankon
通讯作者：
Germiyanoglu, Cankon
DOI：
10.2174/187221311794474847
发表时间：
2011-01-01
影响因子：
4.2
作者：
Benhanifia, Mokhtar B.;Boukraa, Laid;Manivannan, Lavaniya
通讯作者：
Manivannan, Lavaniya