Asthma microbiome studies and the potential for new therapeutic strategies.
Asthma microbiome studies and the potential for new therapeutic strategies.
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DOI：
10.1007/s11882-013-0355-y
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发表时间：
2013-10
影响因子：
5.5
通讯作者：
Huang, Yvonne J.
中科院分区：
文献类型：
--
作者：
Huang, Yvonne J.
关键词：
最近应用的微生物组分析的非培养工具揭示了哮喘和与环境，肠道或气道相关的微生物群之间的重要关系。特别是对气道微生物组的研究代表了肺部研究的新前沿。虽然这些研究相对较新，但目前的证据表明，有可能采用新的治疗策略来治疗或预防哮喘。在这篇文章中，对微生物群和哮喘的最新文献进行了严格的审查，特别关注气道微生物组的研究。本文介绍了微生物组与哮喘之间关系的知识增长如何可能转化为对哮喘发病机制、异质性和新治疗方法的机会的更好理解。
Recent applications of culture-independent tools for microbiome profiling have revealed significant relationships between asthma and microbiota associated with the environment, gut or airways. Studies of the airway microbiome in particular represent a new frontier in pulmonary research. Although these studies are relatively new, current evidence suggests the possibility of new therapeutic strategies for the treatment or prevention of asthma. In this article, recent literature on microbiota and asthma are critically reviewed, with a particular focus on studies of the airway microbiome. Perspectives are presented on how growing knowledge of relationships between the microbiome and asthma is likely to translate into improved understanding of asthma pathogenesis, its heterogeneity, and opportunities for novel treatment approaches.
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影响因子：
2.5
作者：
Abt MC;Artis D
通讯作者：
Artis D
影响因子：
3.7
作者：
Lødrup Carlsen KC;Roll S;Carlsen KH;Mowinckel P;Wijga AH;Brunekreef B;Torrent M;Roberts G;Arshad SH;Kull I;Krämer U;von Berg A;Eller E;Høst A;Kuehni C;Spycher B;Sunyer J;Chen CM;Reich A;Asarnoj A;Puig C;Herbarth O;Mahachie John JM;Van Steen K;Willich SN;Wahn U;Lau S;Keil T;GALEN WP 1.5 ‘Birth Cohorts’ working group
通讯作者：
GALEN WP 1.5 ‘Birth Cohorts’ working group
影响因子：
3.7
作者：
Erb-Downward JR;Thompson DL;Han MK;Freeman CM;McCloskey L;Schmidt LA;Young VB;Toews GB;Curtis JL;Sundaram B;Martinez FJ;Huffnagle GB
通讯作者：
Huffnagle GB
影响因子：
14.2
作者：
Heederik, Dick;von Mutius, Erika
通讯作者：
von Mutius, Erika
DOI：
10.1016/j.jaci.2010.10.048
发表时间：
2011-02
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
Huang YJ;Nelson CE;Brodie EL;Desantis TZ;Baek MS;Liu J;Woyke T;Allgaier M;Bristow J;Wiener-Kronish JP;Sutherland ER;King TS;Icitovic N;Martin RJ;Calhoun WJ;Castro M;Denlinger LC;Dimango E;Kraft M;Peters SP;Wasserman SI;Wechsler ME;Boushey HA;Lynch SV;National Heart, Lung, and Blood Institute's Asthma Clinical Research Network
通讯作者：
National Heart, Lung, and Blood Institute's Asthma Clinical Research Network