Cytokines in psoriasis.
Cytokines in psoriasis.
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DOI：
10.1016/j.cyto.2014.12.014
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发表时间：
2015-06
期刊：
影响因子：
3.8
通讯作者：
Johnston, Andrew
中科院分区：
文献类型：
--
作者：
Baliwag, Jaymie;Barnes, Drew H.;Johnston, Andrew
银屑病是一种常见的炎症性皮肤病，其病因尚不完全清楚。该疾病的特征是由表皮角质形成细胞过度增殖形成的红色、鳞片和边界清楚的皮肤损害。这种过度增殖是由激活的常驻免疫细胞、T细胞、树突状细胞和天然免疫系统的细胞以及角质形成细胞本身分泌的细胞因子推动的。银屑病具有很强的遗传性，具有复杂的遗传背景。全基因组关联研究发现，在一些编码细胞因子、细胞因子受体或其信号转导途径元件的基因内或附近存在多态性，进一步表明这些细胞因子与银屑病的发病机制有关。大量炎性细胞因子已被证明在银屑病皮损中升高，其中一部分的血清浓度也与银屑病的严重程度相关。在银屑病皮损中发现的细胞因子的联合作用可能解释了银屑病的大部分临床特征，如角质形成细胞过度增殖，新生血管增加和皮肤炎症。因此，了解哪些细胞因子在疾病过程中起着关键作用，可以提出潜在的治疗靶点。一些细胞因子已经成功地以治疗为靶点，使这种疾病的治疗发生了革命性的变化。在这里，我们回顾了一些与银屑病发病机制有关的关键细胞因子。
Psoriasis is a common inflammatory skin disease with an incompletely understood etiology. The disease is characterized by red, scaly and well-demarcated skin lesions formed by the hyperproliferation of epidermal keratinocytes. This hyperproliferation is driven by cytokines secreted by activated resident immune cells, an infiltrate of T cells, dendritic cells and cells of the innate immune system, as well as the keratinocytes themselves. Psoriasis has a strong hereditary character and has a complex genetic background. Genome-wide association studies have identified polymorphisms within or near a number of genes encoding cytokines, cytokine receptors or elements of their signal transduction pathways, further implicating these cytokines in the psoriasis pathomechanism. A considerable number of inflammatory cytokines have been shown to be elevated in lesional psoriasis skin, and the serum concentrations of a subset of these also correlate with psoriasis disease severity. The combined effects of the cytokines found in psoriasis lesions likely explain most of the clinical features of psoriasis, such as the hyperproliferation of keratinocytes, increased neovascularization and skin inflammation. Thus, understanding which cytokines play a pivotal role in the disease process can suggest potential therapeutic targets. A number of cytokines have been therapeutically targeted with success, revolutionizing treatment of this disease. Here we review a number of key cytokines implicated in the pathogenesis of psoriasis.
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DOI：
10.4049/jimmunol.1301481
发表时间：
2014-06-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
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发表时间：
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期刊：
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DOI：
10.1111/j.1468-3083.2012.04582.x
发表时间：
2013-06
期刊：
Journal of the European Academy of Dermatology and Venereology : JEADV
影响因子：
--
作者：
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影响因子：
16.6
作者：
Desmet, Johan;Verstraete, Kenneth;Bloch, Yehudi;Lorent, Eric;Wen, Yurong;Devreese, Bart;Vandenbroucke, Karen;Loverix, Stefan;Hettmann, Thore;Deroo, Sabrina;Somers, Klaartje;Henderikx, Paula;Lasters, Ignace;Savvides, Savvas N.
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