The Representation of Gender and Race/Ethnic Groups in Randomized Clinical Trials of Individuals with Systemic Lupus Erythematosus.
The Representation of Gender and Race/Ethnic Groups in Randomized Clinical Trials of Individuals with Systemic Lupus Erythematosus.
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DOI：
10.1007/s11926-018-0728-2
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发表时间：
2018-03-17
影响因子：
5
通讯作者：
Simard JF
中科院分区：
文献类型：
--
作者：
Falasinnu T;Chaichian Y;Bass MB;Simard JF
本综述评价了系统性红斑狼疮（SLE）患者随机对照试验（RCT）中的性别和种族/民族代表性。白人占SLE流行病例的33%，占RCT入组者的51%。黑人占SLE流行病例的43%，但仅占RCT登记者的14%。西班牙裔占16%的流行SLE病例和21%的RCT登记者，而亚洲人占13%的流行SLE病例和10%的RCT登记者。男性包括9%的SLE病例和7%的RCT入组者。男性的报告和代表性随着时间的推移保持稳定，尽管他们在RCT中的代表性略低于男性SLE的患病率。随着时间的推移，西班牙裔，亚洲人和美洲原住民的代表性有所增加。然而，自2006-2011年以来，RCT参与者中黑人的比例有所下降。SLE患者中的RCT需要更大的样本量，以评估种族亚组之间结局的异质性。当务之急是开发新的策略，通过识别和改善RCT招募的障碍，以更好地了解疾病的多样化人群，招募SLE少数民族。
This review evaluated gender and race/ethnic representation in randomized controlled trials (RCTs) of patients with systemic lupus erythematosus (SLE). Whites comprise 33% of prevalent SLE cases and comprised 51% of RCT enrollees. Blacks encompass 43% of prevalent SLE cases, but only represented 14% of RCT enrollees. Hispanics comprise 16% of prevalent SLE cases and 21% of RCT enrollees, while Asians comprise 13% of prevalent SLE cases and 10% of RCT enrollees. Males encompass 9% of SLE cases and 7% of RCT enrollees. The reporting and representation of males have remained stable over time, although their representation in RCTs is slighter lower than the prevalence of SLE in males. The representation of Hispanics, Asians, and Native Americans increased over time. However, the representation of blacks among RCT participants has decreased since 2006–2011. RCTs among SLE patients need larger sample sizes in order to evaluate heterogeneity in outcomes among racial subgroups. It is imperative that novel strategies be developed to recruit racial minorities with SLE by identifying and improving barriers to RCT enrollment in order to better understand the disease’s diverse population.
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影响因子：
9.1
作者：
Weckerle, Corinna E.;Niewold, Timothy B.
通讯作者：
Niewold, Timothy B.
影响因子：
2.6
作者：
Munoz-Grajales, C.;Gonzalez, L. A.;Acosta-Reyes, J.
通讯作者：
Acosta-Reyes, J.
影响因子：
--
作者：
Napoles A;Cook E;Ginossar T;Knight KD;Ford ME
通讯作者：
Ford ME
影响因子：
5.6
作者：
Mak A;Tay SH
通讯作者：
Tay SH
影响因子：
13.3
作者：
Dall'Era, Maria;Cisternas, Miriam G.;Helmick, Charles G.
通讯作者：
Helmick, Charles G.