Isolation driven changes in Iba1-positive microglial morphology are associated with social recognition memory in adults and adolescents.
Isolation driven changes in Iba1-positive microglial morphology are associated with social recognition memory in adults and adolescents.
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Iba1阳性小胶质细胞形态的隔离驱动变化与成人和青少年的社会识别记忆相关。
DOI：
10.1016/j.nlm.2022.107626
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发表时间：
2022-07
影响因子：
2.7
通讯作者：
Rosenkranz, J. Amiel
中科院分区：
文献类型：
--
作者：
Ferrara, Nicole C.;Trask, Sydney;Yan, Lily;Padival, Mallika;Helmstetter, Fred J.;Rosenkranz, J. Amiel
小胶质细胞对于调节从青春期到成年期成熟的神经元回路至关重要。小胶质细胞的形态复杂性和突起长度可以指示不同的激活状态。这些状态对各种环境和压力条件敏感。小胶质细胞对许多调节社会行为的因素敏感，反过来，小胶质细胞的操纵可以影响社会功能。短暂的社会孤立是可能导致社会剧烈变化的一个因素。在这里，我们探讨了小胶质细胞在短暂的社会隔离对社会识别记忆的影响中的作用。使用Iba1的形态学指标来指示小胶质细胞的强度、复杂性和过程长度，我们确定了短暂隔离对成人和青少年之间杏仁核基底区小胶质细胞复杂性的不同影响，以及Iba1在几个皮层脑区的强度的总体增加。短期社会认知记忆对社会参与的数量很敏感，并提供了一个机会来测试短暂隔离产生的社会参与是否以依赖于小胶质细胞的方式增强社会学习。我们发现，短暂的孤立促进了不同年龄段的社会互动，但对短期社会认可产生了相反的影响。隔离增加了新的合作伙伴调查的青少年，这是符合更好的社会认可，但增加了熟悉的合作伙伴调查在成年人。用PLX3397耗尽小胶质细胞可以防止青少年短暂隔离的这些影响，并减少成年人的影响。这些结果表明，由社会环境驱动的小胶质细胞功能的明显变化可能对随后的社会识别记忆在发育过程中有不同的贡献。
Microglia are critical for regulation of neuronal circuits that mature from adolescence to adulthood. The morphological complexity and process length of microglia can indicate different activation states. These states are sensitive to a variety of environmental and stress conditions. Microglia are sensitive to many factors that also regulate social behavior, and in turn, microglial manipulations can impact social function. Brief social isolation is one factor that can lead to robust social changes. Here, we explored the role of microglia in the effects of brief social isolation on social recognition memory. Using morphological measures of Iba1 to index microglial intensity, complexity, and process length, we identified different effects of brief isolation on microglial complexity in the basal region of the amygdala between adults and adolescents alongside overall increases in intensity of Iba1 in several cortical brain regions. Short-term social recognition memory is sensitive to the amount of social engagement, and provides an opportunity to test if social engagement produced by brief isolation enhances social learning in a manner that relies on microglia. We found that brief isolation facilitated social interaction across ages but had opposing effects on short-term social recognition. Isolation increased novel partner investigation in adolescents, which is consistent with better social recognition, but increased familiar partner investigation in adults. Depletion of microglia with PLX3397 prevented these effects of brief isolation in adolescents, and reduced them in adults. These results suggest that distinct changes in microglial function driven by the social environment may differentially contribute to subsequent social recognition memory during development.
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影响因子：
5.3
作者：
Karperien A;Ahammer H;Jelinek HF
通讯作者：
Jelinek HF
DOI：
10.1002/cne.22359
发表时间：
2010-07-15
期刊：
The Journal of comparative neurology
影响因子：
--
作者：
Cressman VL;Balaban J;Steinfeld S;Shemyakin A;Graham P;Parisot N;Moore H
通讯作者：
Moore H
影响因子：
5.6
作者：
Ferrara, Nicole C.;Mrackova, Eliska;Rosenkranz, J. Amiel
通讯作者：
Rosenkranz, J. Amiel
影响因子：
4
作者：
Foilb, Allison R.;Lui, Patina;Romeo, Russell D.
通讯作者：
Romeo, Russell D.
影响因子：
5.3
作者：
Arruda-Carvalho, Maithe;Wu, Wan-Chen;Clem, Roger L.
通讯作者：
Clem, Roger L.