Angiogenic and inflammatory biomarkers in midpregnancy and small-for-gestational-age outcomes in Tanzania.
Angiogenic and inflammatory biomarkers in midpregnancy and small-for-gestational-age outcomes in Tanzania.
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DOI：
10.1016/j.ajog.2014.05.032
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发表时间：
2014-11
影响因子：
9.8
通讯作者：
Fawzi, Wafaie W.
中科院分区：
文献类型：
--
作者：
Darling, Anne Marie;McDonald, Chloe R.;Conroy, Andrea L.;Hayford, Kyla T.;Liles, W. Conrad;Wang, Molin;Aboud, Said;Urassa, Willy S.;Kain, Kevin C.;Fawzi, Wafaie W.
研究撒哈拉以南非洲地区妊娠中期测量的一组血管生成和炎症生物标志物与小于胎龄儿（SGA）结局之间的关系。在坦桑尼亚达累斯萨拉姆的432名孕妇中测定了18种血管生成和炎症生物标志物的浓度，这些孕妇参加了一项研究多种维生素对妊娠结局影响的试验。相对于应用的生长标准，低于胎龄出生体重第10百分位数的婴儿被视为SGA。采用多变量二项回归模型和对数连接函数来确定与每种生物标志物的四分位数增加相关的SGA的相对风险。逐步三次限制样条用于测试这些关联的非线性。从多变量逻辑回归模型获得的受试者工作曲线用于评估所选生物标志物的区分能力。共有60名参与者（13.9%）生下了SGA婴儿。与第一个四分位数相比，第四个四分位数VEGF-A的患者发生SGA的风险降低（校正风险比（RR）0.38，95%置信区间（CI），0.19-0.74），PGF（校正RR 0.28，95% CI，0.12-0.61），sFlt-1（校正RR 0.48，95% CI，0.23-1.01），MCP-1（调整后RR 0.48，95% CI，0.25-0.92）和瘦素（调整后的RR 0.46，95% CI，0.22-0.96）我们的研究结果提供了在妊娠中期，继续分娩小于胎龄儿的妇女中血管生成和炎症介质改变的证据。
To investigate the relationship between a panel of angiogenic and inflammatory biomarkers measured in mid-pregnancy and small-for-gestational age (SGA) outcomes in sub-Saharan Africa. Concentrations of 18 angiogenic and inflammatory biomarkers were determined in 432 pregnant women in Dar es Salaam, Tanzania who participated in a trial examining the effect of multivitamins on pregnancy outcomes. Infants falling below the 10th percentile of birth weight for gestational age relative to the applied growth standards were considered SGA. Multivariate binomial regression models with the log link function were used to determine the relative risk of SGA associated with increasing quartiles of each biomarker. Stepwise cubic restricted splines were used to test for non-linearity of these associations. Receiver operating curves obtained from multivariate logistic regression models were used to assess the discriminatory capability of selected biomarkers. A total of 60 participants (13.9%) gave birth to SGA infants. Compared to those in the first quartile, the risk of SGA was reduced among those in the fourth quartiles of VEGF-A (adjusted risk ratio (RR) 0.38, 95% Confidence Interval (CI), 0.19-0.74), PGF (adjusted RR 0.28, 95% CI, 0.12-0.61), sFlt-1 (adjusted RR 0.48, 95% CI, 0.23-1.01), MCP-1 (adjusted RR 0.48, 95% CI, 0.25-0.92), and Leptin (adjusted RR 0.46, 95% CI, 0.22-0.96) Our findings provide evidence of altered angiogenic and inflammatory mediators, at mid-pregnancy, in women who went on to deliver small for gestational age infants.
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影响因子：
9.8
作者：
Maynard, Sharon E.;Simas, Tiffany A. Moore;Meyer, Bruce A.
通讯作者：
Meyer, Bruce A.
影响因子：
2
作者：
DURRLEMAN, S;SIMON, R
通讯作者：
SIMON, R
宫内血浆单核细胞趋化蛋白1浓度在宫内生长限制中。
影响因子：
4.6
作者：
Briana, Despina D.;Boutsikou, Maria;Baka, Stavroula;Papadopoulos, George;Gourgiotis, Dimitrios;Puchner, Karl Philipp;Hassiakos, Dimitrios;Malamitsi-Puchner, Ariadne
通讯作者：
Malamitsi-Puchner, Ariadne
影响因子：
2.5
作者：
Boutsikou, Theodora;Malamitsi-Puchner, Ariadne;Hassiakos, Dimitrios
通讯作者：
Hassiakos, Dimitrios
影响因子：
158.5
作者：
Fawzi, Wafaie W.;Msamanga, Gernard I.;Spiegelman, Donna
通讯作者：
Spiegelman, Donna