Binary cell death decision regulated by unequal partitioning of Numb at mitosis.
Binary cell death decision regulated by unequal partitioning of Numb at mitosis.
复制标题
有丝分裂时 Numb 的不等分配调节二元细胞死亡决策。
作者：
V. Orgogozo;F. Schweisguth;Y. Bellaïche
后生动物发育中的一个重要问题是了解导致程序性细胞死亡的刻板印象模式的机制。特别是，被编程死亡的细胞可能是由不对称的细胞分裂引起的。这种二元细胞死亡决定背后的机制尚不清楚。我们在这里描述了一种果蝇感觉器官谱系，它在胚胎中产生一个单一的多树突状神经元。这种血统包括两个不对称的分裂。每次分裂后，两个子细胞中的一个细胞表达促凋亡基因REPAR和GREAM，随后死亡。蛋白质Numb似乎是不会死亡的子细胞所特有的遗传。在这个谱系中，数量是防止细胞凋亡所必需且足够的。相反，激活的缺口足以在这个血统中触发死亡。这些结果表明，二元细胞死亡决定可以由有丝分裂时数量的不均匀分离来调节。我们的研究还表明，程序性细胞死亡的调节以片段特异性的方式调节感觉器官的最终模式。
An important issue in Metazoan development is to understand the mechanisms that lead to stereotyped patterns of programmed cell death. In particular, cells programmed to die may arise from asymmetric cell divisions. The mechanisms underlying such binary cell death decisions are unknown. We describe here a Drosophila sensory organ lineage that generates a single multidentritic neuron in the embryo. This lineage involves two asymmetric divisions. Following each division, one of the two daughter cells expresses the pro-apoptotic genes reaper and grim and subsequently dies. The protein Numb appears to be specifically inherited by the daughter cell that does not die. Numb is necessary and sufficient to prevent apoptosis in this lineage. Conversely, activated Notch is sufficient to trigger death in this lineage. These results show that binary cell death decision can be regulated by the unequal segregation of Numb at mitosis. Our study also indicates that regulation of programmed cell death modulates the final pattern of sensory organs in a segment-specific manner.
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