Treadmill exercise training prevents myocardial mechanical dysfunction induced by androgenic-anabolic steroid treatment in rats.
Treadmill exercise training prevents myocardial mechanical dysfunction induced by androgenic-anabolic steroid treatment in rats.
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DOI：
10.1371/journal.pone.0087106
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Campos RR
中科院分区：
文献类型：
--
作者：
Bocalini DS;Beutel A;Bergamaschi CT;Tucci PJ;Campos RR
睾酮及其合成类似物浓度升高可能会引起心血管功能的变化。然而，合成代谢/雄激素类固醇（AAS）治疗与运动训练相结合对心脏收缩和舒张功能的影响尚不清楚。在本研究中，我们旨在研究低剂量类固醇治疗（康力龙）与大鼠运动训练相结合时对心脏收缩参数的影响，以及慢性类固醇治疗对 Frank-Starling（长度-张力曲线）关系的影响。雄性 Wistar 大鼠被随机分配到四组之一：U（未经训练）、US（未经训练并用康力龙 5 mg/kg/周治疗）、T（经过训练，16 m/min/1 h）和 TS（训练并用康力龙 5 mg/kg/周治疗）。持续运动训练每周5天，连续8周。跑步机的速度逐渐增加至最终设置为 16 m/min/1 h。实验分为两个独立系列：1）平均动脉血压（MAP）和心输出量（CO）测量的中心血流动力学分析，2）在克雷布斯溶液中分离乳头肌制备。康力龙治疗显着增加了未经训练和训练过的大鼠的 MAP 和心脏大小（U 113±2；T 106±2；US 138±8 和 TS 130±7 mmHg）。此外，康力龙显着降低 U 大鼠的张力和 dT/dt（最大和最小）。然而，紧张的情绪通过训练完全恢复了。接受康力龙治疗的大鼠中，Frank/Starling 关系受损；然而，训练再次完全恢复了舒张功能。综上所述，目前的数据表明 AAS 治疗能够降低心脏功能（收缩功能和舒张功能）。康力龙与体育训练相结合可改善心脏功能，包括舒张和收缩功能，且与中心血流动力学参数的变化无关。因此，心室肌细胞钙瞬变的变化可能起到心脏保护作用。
Elevated concentrations of testosterone and its synthetic analogs may induce changes in cardiovascular function. However, the effects of the combination of anabolic/androgenic steroid (AAS) treatment and exercise training on systolic and diastolic cardiac function are poorly understood. In the present study, we aimed to investigate the effects of low-dose steroid treatment (stanozolol) on cardiac contractile parameters when this steroid treatment was combined with exercise training in rats and the effects of chronic steroid treatment on the Frank-Starling (length-tension curves) relationship. Male Wistar rats were randomly assigned to one of four groups: U (untrained), US (untrained and treated with stanozolol 5 mg/kg/week), T (trained, 16 m/min/1 h) and TS (trained and treated with stanozolol 5 mg/kg/week). Continuous exercise training was conducted 5 days/week for 8 consecutive weeks. The speed of the treadmill was gradually increased to a final setting of 16 m/min/1 h. Experiments were divided into two independent series: 1) central hemodynamic analysis for mean arterial blood pressure (MAP) and cardiac output (CO) measurements and 2) isolated papillary muscle preparation in Krebs solution. Stanozolol treatment significantly increased the MAP and the heart size in untrained and trained rats (U 113±2; T 106±2; US 138±8 and TS 130±7 mmHg). Furthermore, stanozolol significantly decreased developed tension and dT/dt (maximal and minimal) in U rats. However, the developed tension was completely restored by training. The Frank/Starling relationship was impaired in rats treated with stanozolol; however, again, training completely restored diastolic function. Taken together, the present data suggest that AAS treatment is able to decrease cardiac performance (systolic and diastolic functions). The combination of stanozolol and physical training improved cardiac performance, including diastolic and systolic functions, independent of changes in central hemodynamic parameters. Therefore, changes in ventricular myocyte calcium transients may play a cardioprotective role.
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DOI：
10.1249/01.mss.0000106173.81966.90
发表时间：
2004-01-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Ketelhut, RG;Franz, IW;Scholze, J
通讯作者：
Scholze, J
DOI：
10.1097/00005768-199708000-00010
发表时间：
1997-08-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Lu, SS;Lau, CP;Wang, PS
通讯作者：
Wang, PS
影响因子：
--
作者：
MALHOTRA, A;BUTTRICK, P;SCHEUER, J
通讯作者：
SCHEUER, J
影响因子：
20.1
作者：
MCGILL, HC;SHERIDAN, PJ
通讯作者：
SHERIDAN, PJ
影响因子：
--
作者：
KOCHAKIAN, CD;ROBERTSON, E;BARTLETT, MN
通讯作者：
BARTLETT, MN