Conditioned lick behavior and evoked responses using whisker twitches in head restrained rats.

Conditioned lick behavior and evoked responses using whisker twitches in head restrained rats.
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DOI:
10.1016/j.bbr.2008.07.032
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发表时间:
2009-01-30
影响因子:
2.7
通讯作者:
Rector, David M.
Rector, David M.
中科院分区:
心理学3区
文献类型:
--
作者:
Topchiy, Irina A.;Wood, Rachael M.;Peterson, BreeAnne;Navas, Jinna A.;Rojas, Manuel.;Rector, David M.

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To examine whisker barrel evoked response potentials in chronically implanted rats during behavioral learning with very fast response times, rats must be calm while immobilized with their head restrained. We quantified their behaviors during training with an ethogram and measured each individual animals’ progress over the training period. Once calm under restraint, rats were conditioned to differentiate between a reward and control whisker twitch, then provide a lick response when presented with the correct stimulus, rewarded by a drop of water. Rats produced the correct licking response (after reward whisker twitch), and learned not to lick after a control whisker was twitched. By implementing a high density 64 channel electrocorticogram (ECoG) electrode array, we mapped the barrel field of the somatosensory cortex with high spatial and temporal resolution during conditioned lick behaviors. In agreement with previous reports, we observe a larger evoked response after training, probably related to mechanisms of cortical plasticity.
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期刊: BRAIN RESEARCH
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