Host Sex Steroids Interact With Virus Infection: New Insights Into Sex Disparity in Infectious Diseases.
Host Sex Steroids Interact With Virus Infection: New Insights Into Sex Disparity in Infectious Diseases.
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宿主性类固醇与病毒感染相互作用：对传染病性别差异的新见解
DOI：
10.3389/fmicb.2021.747347
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发表时间：
2021
影响因子：
5.2
通讯作者：
Wang X
中科院分区：
文献类型：
--
作者：
Wu J;Zhang L;Wang X
性激素是由动物性腺和胎盘、肾上腺皮质网状带等组织合成的类固醇激素。性激素的生理功能是复杂的。性激素不仅与许多生殖系统疾病有病理相关性，而且是某些病毒感染性疾病的致病因素，包括冠状病毒、疱疹病毒、肝炎病毒和其他类型的人类病毒感染引起的疾病，这些疾病在临床实践中表现出男性倾向，或者在病毒发病机制中与雄激素受体（AR）相关途径相互干扰。由于2019年冠状病毒病全球大流行，（COVID-19），雄激素/AR在病毒感染性疾病中的作用再次被强调，主要表现为跨膜蛋白酶/丝氨酸亚家族成员2（TMPRSS 2）的AR应答基因的最新进展，其蛋白水解激活许多冠状病毒和流感病毒的受体介导的病毒进入，沿着雄激素介导的信号传导在B肝炎病毒（HBV）转录中的作用，以及性激素应答基因在寨卡病毒（ZIKV）发病过程中的作用，我们建议全面概述男性性激素在不同人类病毒生命周期的多个阶段中的作用，这可能是造成性别特异性流行的部分原因，因此，某些疾病的严重程度和死亡率可能为制定针对高危人群的更有效预防和治疗战略提供线索。
Sex hormones are steroid hormones synthesized from the gonads of animals and tissues such as the placenta and adrenocortical reticular zone. The physiological functions of sex hormones are complex. Sex hormones are not only pathologically correlated with many diseases of the reproductive system, but are etiological factors in some viral infectious diseases, including disease caused by infections of coronaviruses, herpesviruses, hepatitis viruses, and other kinds of human viruses, which either exhibit a male propensity in clinical practice, or crosstalk with androgen receptor (AR)-related pathways in viral pathogenesis. Due to the global pandemic of coronavirus disease 2019 (COVID-19), the role of androgen/AR in viral infectious disease is highlighted again, majorly representing by the recent advances of AR-responsive gene of transmembrane protease/serine subfamily member 2 (TMPRSS2), which proteolytically activates the receptor-mediated virus entry by many coronaviruses and influenza virus, along with the role of androgen-mediated signaling for the transcription of hepatitis B virus (HBV), and the role of sex hormone responsive genes during Zika virus (ZIKV) pathogenesis, et al. Collectively, we propose to provide a comprehensive overview of the role of male sex hormones during multiple phases in the life cycle of different human viruses, which may be partly responsible for the sex-specific prevalence, severity and mortality of some diseases, therefore, may provide clues to develop more efficient prevention and treatment strategies for high-risk populations.
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