Regulation of subcutaneous adipose tissue blood flow is related to measures of vascular and autonomic function.
Regulation of subcutaneous adipose tissue blood flow is related to measures of vascular and autonomic function.
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皮下脂肪组织血流的调节与血管和自主神经功能的测量有关。
DOI：
10.1042/cs20100066
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Funada J
中科院分区：
文献类型：
--
作者：
Funada J
适当的血管功能对心血管健康很重要。脂肪组织在代谢稳态中起着重要作用，并且皮下腹部ATBF（脂肪组织血流）对营养刺激有反应。这种反应在肥胖症中受损，表明与内皮功能相似。在本研究中，我们评估了ATBF的调节是否与肱动脉的FMD（血流介导的血管舒张）评估的内皮功能的调节有关。FMD受损是动脉粥样硬化风险的标志，因此我们也评估了ATBF和动脉粥样硬化标志物颈总动脉IMT（内膜中层厚度）之间的关系。由于ATBF对交感-肾上腺刺激有反应，我们还研究了与HRV（心率变异性）的关系。共有79名健康志愿者（44名女性）在空腹和摄入75 g葡萄糖后进行了研究。FMD、空腹ATBF和ATBF对葡萄糖的反应性均与BMI（体重指数）呈负相关，证实了肥胖对心血管的不良影响。FMD与空腹ATBF相关（rs= 0.32，P =0.008），至少在男性中，这种关系与BMI无关（P=0.02）。在一部分参与者中测量的颈总动脉IMT与空腹ATBF呈负相关[rs=-0.51，P =0.02（n=20）]。另一方面，ATBF对葡萄糖的反应性与FMD或IMT无关。在多元回归模型中，空腹和刺激ATBF与HRV均相关。总之，我们的研究结果表明，ATBF的调节与内皮功能有共同的特点，但也与自主心血管控制反映在HRV的关系。
Appropriate blood vessel function is important to cardiovascular health. Adipose tissue plays an important role in metabolic homoeostasis, and subcutaneous abdominal ATBF (adipose tissue blood flow) is responsive to nutritional stimuli. This response is impaired in obesity, suggesting parallels with endothelial function. In the present study, we assessed whether regulation of ATBF is related to the regulation of endothelial function, assessed by FMD (flow-mediated vasodilatation) of the brachial artery. Impaired FMD is a marker of atherosclerotic risk, so we also assessed relationships between ATBF and a marker of atherosclerosis, common carotid artery IMT (intima-media thickness). As ATBF is responsive to sympatho-adrenal stimuli, we also investigated relationships with HRV (heart rate variability). A total of 79 healthy volunteers (44 female) were studied after fasting and after ingestion of 75 g of glucose. FMD, fasting ATBF and the responsiveness of ATBF to glucose were all negatively related to BMI (body mass index), confirming the adverse cardiovascular effects of adiposity. FMD was related to fasting ATBF (rs=0.32,P=0.008) and, at least in males, this relationship was independent of BMI (P=0.02). Common carotid artery IMT, measured in a subset of participants, was negatively related to fasting ATBF [rs=−0.51,P=0.02 (n=20)]. On the other hand, ATBF responsiveness to glucose had no relationship with either FMD or IMT. In multiple regression models, both fasting and stimulated ATBF had relationships with HRV. In conclusion, our results show that the regulation of ATBF has features in common with endothelial function, but also relationships with autonomic cardiovascular control as reflected in HRV.
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DOI：
10.1016/s0735-1097(00)00758-0
发表时间：
2000-08-01
影响因子：
24
作者：
Raitakari, OT;Lai, N;Celermajer, DS
通讯作者：
Celermajer, DS
阿托伐他汀对血脂、纤溶参数和内皮功能的短期影响存在性别差异。
DOI：
10.1016/j.numecd.2006.10.008
发表时间：
2008
期刊：
Nutrition, metabolism, and cardiovascular diseases : NMCD
影响因子：
--
作者：
K. Sakabe;N. Fukuda;Yamato Fukuda;K. Wakayama;T. Nada;S. Morishita;H. Shinohara;Y. Tamura
通讯作者：
Y. Tamura
饮食引起的人体皮下脂肪组织血流变化：β-肾上腺素受体抑制的作用。
DOI：
10.1111/j.1748-1716.1990.tb08932.x
发表时间：
1990
期刊：
Acta physiologica Scandinavica
影响因子：
--
作者：
L. Simonsen;J. Bülow;A. Astrup;J. Madsen;N. Christensen
通讯作者：
N. Christensen
影响因子：
5
作者：
Chambless, LE;Heiss, G;Clegg, LX
通讯作者：
Clegg, LX
DOI：
10.1253/circj.66.127
发表时间：
2002
期刊：
Circulation journal : official journal of the Japanese Circulation Society
影响因子：
--
作者：
J. Funada;M. Sekiya;M. Hamada;K. Hiwada
通讯作者：
K. Hiwada