Prenatal concentrations of perfluoroalkyl substances and bone health in British girls at age 17.
Prenatal concentrations of perfluoroalkyl substances and bone health in British girls at age 17.
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DOI：
10.1007/s11657-018-0498-5
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发表时间：
2018-08-03
影响因子：
3
通讯作者：
Hartman TJ
中科院分区：
文献类型：
--
作者：
Jeddy Z;Tobias JH;Taylor EV;Northstone K;Flanders WD;Hartman TJ
全氟烷基物质（PFAS）用于制造普通家用产品的保护涂层。产前暴露与后代的发育结果有关。利用雅芳父母和儿童纵向研究（ALSPAC）的数据，我们调查了17岁女孩产前PFAS浓度与骨骼健康之间的关联，以及身体成分是否可以解释任何关联。我们测量了妊娠期间采集的母体血清样本中全氟辛烷磺酸（PFOS）、全氟辛酸（PFOA）、全氟己烷磺酸（PFHxS）和全氟壬酸（PFNA）的浓度。我们获得了女孩的骨健康结果，如骨矿物质密度，骨矿物质含量，骨面积，以及全身双能X射线吸收测定法（DXA）扫描的面积调整骨矿物质含量。我们使用多变量线性回归来探索每个PFAS和每个骨健康结果之间的关联，并调整重要的混杂因素，如女孩在诊所就诊时的年龄，母亲的教育程度和样本收集时的胎龄。我们还控制了女孩的身高和瘦体重，以探索身体成分对观察到的关联的作用。在调整了重要的混杂因素后，产前全氟辛烷磺酸、全氟辛酸、全氟羟硫和全氟萘酸浓度对骨大小和骨质量具有相反的影响。相反，PFNA与区域调整后的骨矿物质含量正相关。然而，最显着的协会衰减后，额外的控制身高和瘦体重。一些PFAS的产前浓度可能与青春期女孩骨量和体型减少有关，尽管尚不清楚这些关联是否由体型驱动。产前暴露于全氟烷基物质（PFAS）与后代的发育结果有关。我们发现，一些PFAS的产前浓度可能与17岁英国女孩的骨量和尺寸减少有关，尽管目前尚不清楚这些关联是否是由身体尺寸驱动的。
Perfluoroalkyl substances (PFAS) are used to make protective coatings on common household products. Prenatal exposures have been associated with developmental outcomes in offspring. Using data from the Avon Longitudinal Study of Parents and Children (ALSPAC), we investigated the association between prenatal concentrations of PFAS and bone health in girls at 17 years of age and whether body composition can explain any associations. We measured concentrations of perfluorooctane sulfonate (PFOS), perfluorooctanoate (PFOA), perfluorohexane sulfonate (PFHxS), and perfluorononanoate (PFNA) in maternal serum samples collected during pregnancy. We obtained bone health outcomes in the girls, such as bone mineral density, bone mineral content, bone area, and area adjusted bone mineral content from whole body dual-energy x-ray absorptiometry (DXA) scans. We used multivariable linear regression to explore associations between each PFAS and each bone health outcome with adjustment for important confounders such as girl’s age at clinic visit, maternal education, and gestational age at sample collection. We also controlled for girl’s height and lean mass to explore the role body composition had on observed associations. Prenatal PFOS, PFOA, PFHxS and PFNA concentrations were associated with inverse effects on bone size and mass after adjusting for important confounders. Conversely, PFNA was positively associated with area-adjusted bone mineral content. However, most significant associations attenuated after additional controlling for height and lean mass. Prenatal concentrations of some PFAS may be associated with reduced bone mass and size in adolescent girls, although it is not clear whether these associations are driven by body size. Prenatal exposures to perfluoroalkyl substances (PFAS) have been associated with developmental outcomes in offspring. We found that prenatal concentrations of some PFAS may be associated with reduced bone mass and size in 17-year-old British girls, although it is not clear whether these associations are driven by body size.
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影响因子：
11.8
作者：
Christensen KY;Maisonet M;Rubin C;Holmes A;Calafat AM;Kato K;Flanders WD;Heron J;McGeehin MA;Marcus M
通讯作者：
Marcus M
影响因子：
10.4
作者：
Calafat, Antonia M;Wong, Lee-Yang;Kuklenyik, Zsuzsanna;Reidy, John A;Needham, Larry L
通讯作者：
Needham, Larry L
影响因子：
5.8
作者：
Sayers, Adrian;Tobias, Jonathan H.
通讯作者：
Tobias, Jonathan H.
DOI：
10.1080/00039890009603403
发表时间：
2000-05-01
期刊：
ARCHIVES OF ENVIRONMENTAL HEALTH
影响因子：
--
作者：
Beard, J;Marshall, S;Bronks, R
通讯作者：
Bronks, R
影响因子：
6.3
作者：
Wallin, E;Rylander, L;Hagmar, L
通讯作者：
Hagmar, L