Icariin intervenes in cardiac inflammaging through upregulation of SIRT6 enzyme activity and inhibition of the NF-kappa B pathway.
Icariin intervenes in cardiac inflammaging through upregulation of SIRT6 enzyme activity and inhibition of the NF-kappa B pathway.
复制标题
淫羊藿苷通过上调 SIRT6 酶活性和抑制 NF-Kappa B 通路干预心脏炎症
DOI：
10.1155/2015/895976
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发表时间：
2015
影响因子：
--
通讯作者：
Xia S
中科院分区：
文献类型：
--
作者：
Chen Y;Sun T;Wu J;Kalionis B;Zhang C;Yuan D;Huang J;Cai W;Fang H;Xia S
本研究旨在探讨淫羊藿苷（伊卡）通过影响SIRT 6酶和NF-κB通路对心脏衰老的影响。研究伊卡对组蛋白去乙酰化酶SIRT 6酶活性的影响，发现10−8 mol/L伊卡对组蛋白去乙酰化酶SIRT 6酶活性的激活作用最大。Western分析显示伊卡上调SIRT 6蛋白表达，下调NF-κB（p65）蛋白表达。伊卡上调SIRT 6的表达，并通过降低NF-κB下游靶基因TNF-α、ICAM-1、IL-2和IL-6的mRNA水平，对NF-κB炎症信号通路具有抑制作用。这些作用直接或间接由SIRT 6介导。我们提供的证据表明，炎症可能涉及伊卡对SIRT 6（衰老调节剂）和NF-κB（炎症调节剂）的作用之间的新联系。
The aim of the study was to investigate the effect of icariin (ICA) on cardiac aging through its effects on the SIRT6 enzyme and on the NF-κB pathway. Investigating the effect of ICA on the enzymatic activity of histone deacetylase SIRT6 revealed a concentration of 10−8 mol/L ICA had a maximum activating effect on histone deacetylase SIRT6 enzymatic activity. Western analysis showed that ICA upregulated SIRT6 protein expression and downregulated NF-κB (p65) protein expression in animal tissues and cell models. ICA upregulated the expression of SIRT6 and had an inhibitory effect on NF-κB inflammatory signaling pathways as shown by decreasing mRNA levels of the NF-κB downstream target genes TNF-α, ICAM-1, IL-2, and IL-6. Those effects were mediated directly or indirectly by SIRT6. We provided evidence that inflammaging may involve a novel link between the effects of ICA on SIRT6 (a regulator of aging) and NF-κB (a regulator of inflammation).
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DOI：
10.1006/bbrc.2000.3000
发表时间：
2000-07-05
影响因子：
3.1
作者：
Frye, RA
通讯作者：
Frye, RA
影响因子：
16.8
作者：
Ginaldil, L;De Martinis, M;Franceschi, C
通讯作者：
Franceschi, C
影响因子：
6.1
作者：
Franceschi, Claudio
通讯作者：
Franceschi, Claudio
影响因子：
64.5
作者：
Kawahara TL;Michishita E;Adler AS;Damian M;Berber E;Lin M;McCord RA;Ongaigui KC;Boxer LD;Chang HY;Chua KF
通讯作者：
Chua KF
影响因子：
3.5
作者：
De Martinis, M;Franceschi, C;Ginaldi, L
通讯作者：
Ginaldi, L