Impact of physical activity on cancer-specific and overall survival of patients with colorectal cancer.
Impact of physical activity on cancer-specific and overall survival of patients with colorectal cancer.
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DOI：
10.1155/2013/340851
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发表时间：
2013
影响因子：
2
通讯作者：
Morere JF
中科院分区：
文献类型：
--
作者：
Des Guetz G;Uzzan B;Bouillet T;Nicolas P;Chouahnia K;Zelek L;Morere JF
背景体力活动（PA）可降低结直肠癌（CRC）的发病率。其对癌症特异性（CSS）和总生存期（OS）的影响存在争议。方法.我们对PubMed和EMBASE中的观察性研究进行了基于文献的荟萃分析（MA），使用关键词“结直肠癌，体力活动和生存率”。在科克伦库中未发现专用MA。对参考文献进行了交叉核对。采用MET评估诊断前和诊断后PA水平。通常，“高”PA高于17 MET小时/周。计算OS和CSS的风险比（HR）及其95%置信区间。我们使用了更保守的校正HR，因为研究之间的校正变量相似。当较高的PA与生存率的改善相关时，有害事件的HR被设定为<1。我们尽可能使用EasyMA软件和固定效应模型。结果纳入了7项研究（8056名参与者），代表3762名男性和4256名女性，5210名结肠癌和1745名直肠癌。平均年龄为67岁。诊断后PA的HR CSS（PA较高vs较低）为0.61（0.44-0.86）。相应的HR OS为0.62（0.54-0.71）。诊断前PA的HR CSS为0.75（0.62-0.91）。相应的HR OS为0.74（0.62-0.89）。结论较高的PA预测较好的CSS。对于CRC，应建议持续性PA。OS也有所改善（降低心血管风险）。
Background. Physical activity (PA) reduces incidence of colorectal cancer (CRC). Its influence on cancer-specific (CSS) and overall survival (OS) is controversial. Methods. We performed a literature-based meta-analysis (MA) of observational studies, using keywords “colorectal cancer, physical activity, and survival” in PubMed and EMBASE. No dedicated MA was found in the Cochrane Library. References were cross-checked. Pre- and postdiagnosis PA levels were assessed by MET. Usually, “high” PA was higher than 17 MET hour/week. Hazard ratios (HRs) for OS and CSS were calculated, with their 95% confidence interval. We used more conservative adjusted HRs, since variables of adjustment were similar between studies. When higher PA was associated with improved survival, HRs for detrimental events were set to <1. We used EasyMA software and fixed effect model whenever possible. Results. Seven studies (8056 participants) were included, representing 3762 men and 4256 women, 5210 colon and 1745 rectum cancers. Mean age was 67 years. HR CSS for postdiagnosis PA (higher PA versus lower) was 0.61 (0.44–0.86). The corresponding HR OS was 0.62 (0.54–0.71). HR CSS for prediagnosis PA was 0.75 (0.62–0.91). The corresponding HR OS was 0.74 (0.62–0.89). Conclusion. Higher PA predicted a better CSS. Sustained PA should be advised for CRC. OS also improved (reduced cardiovascular risk).
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结直肠癌女性的休闲体育锻炼，体重指数和生存。
影响因子：
2.3
作者：
Kuiper, Josephina G.;Phipps, Amanda I.;Neuhouser, Marian L.;Chlebowski, Rowan T.;Thomson, Cynthia A.;Irwin, Melinda L.;Lane, Dorothy S.;Wactawski-Wende, Jean;Hou, Lifang;Jackson, Rebecca D.;Kampman, Ellen;Newcomb, Polly A.
通讯作者：
Newcomb, Polly A.
影响因子：
45.3
作者：
Campbell, Peter T.;Patel, Alpa V.;Gapstur, Susan M.
通讯作者：
Gapstur, Susan M.
影响因子：
--
作者：
Meyerhardt, Jeffrey A.;Giovannucci, Edward L.;Fuchs, Charles S.
通讯作者：
Fuchs, Charles S.
影响因子：
254.7
作者：
Rock, Cheryl L.;Doyle, Colleen;Gansler, Ted
通讯作者：
Gansler, Ted
影响因子：
3.7
作者：
Ma Y;Yang Y;Wang F;Zhang P;Shi C;Zou Y;Qin H
通讯作者：
Qin H