Spatial modulation of hippocampal activity in freely moving macaques.
Spatial modulation of hippocampal activity in freely moving macaques.
复制标题
DOI：
10.1016/j.neuron.2021.09.032
复制
发表时间：
2021-11-03
期刊：
影响因子：
16.2
通讯作者：
Angelaki DE
中科院分区：
文献类型：
--
作者：
Mao D;Avila E;Caziot B;Laurens J;Dickman JD;Angelaki DE
海马体结构与空间导航有关，但来自自由活动的灵长类动物以及同时监测头部和凝视姿势的证据很少。我们记录了恒河猴在开放环境中自由觅食期间海马区的神经活动，同时跟踪了它们的头和眼睛。Theta活动在运动开始时间歇性存在，并受到眼跳的调节。许多神经元被锁相到theta，很少有神经元出现相位进动。除了位置和网格调谐之外，大多数神经元还编码空间变量的混合。空间表征主要受朝向位置和偏心方向的支配，主要是头部坐标，而不是凝视坐标。重要的是，眼球运动强烈地调节了所有区域的神经活动。这些发现表明，猕猴的海马体结构使用多路编码来代表三维空间，在自由探索过程中，头部方向和眼球运动特性占主导地位。利用无线记录，头部和眼睛跟踪自由行为的猕猴，毛等人。发现海马体的活动被调整到，最引人注目的是，头部指向的位置，3D头部方向和眼球运动。这些结果证明了该灵长类物种在行为学条件下的空间表征的特殊性。
The hippocampal formation is linked to spatial navigation, but there is little corroboration from freely-moving primates with concurrent monitoring of head and gaze stances. We recorded neural activity across hippocampal regions in rhesus macaques during free foraging in an open environment while tracking their head and eye. Theta activity was intermittently present at movement onset and modulated by saccades. Many neurons were phase-locked to theta, with few showing phase precession. Most neurons encoded a mixture of spatial variables beyond place and grid tuning. Spatial representations were dominated by facing location and allocentric direction, mostly in head, rather than gaze, coordinates. Importantly, eye movements strongly modulated neural activity in all regions. These findings reveal that the macaque hippocampal formation represents three-dimensional space using a multiplexed code, with head orientation and eye movement properties being dominant during free exploration. Leveraging wireless recordings, head and eye tracking in freely behaving macaques, Mao et al. find that hippocampal activity is tuned to, most strikingly, where the head points, 3D head orientation, and eye movements. These results demonstrate the peculiarities of spatial representations in this primate species under ethological conditions.
登录
查看更多内容
影响因子：
3.5
作者：
Fyhn, Marianne;Hafting, Torkel;Moser, May-Britt
通讯作者：
Moser, May-Britt
影响因子：
64.8
作者：
Ekstrom, AD;Kahana, MJ;Fried, I
通讯作者：
Fried, I
影响因子：
16.6
作者：
Goyal, Abhinav;Miller, Jonathan;Jacobs, Joshua
通讯作者：
Jacobs, Joshua
影响因子：
16.6
作者：
Angelaki, Dora E.;Ng, Julia;Laurens, Jean
通讯作者：
Laurens, Jean
影响因子：
3.5
作者：
Furuya, Yoichi;Matsumoto, Jumpei;Nishijo, Hisao
通讯作者：
Nishijo, Hisao