Annotation of the Asian Citrus Psyllid Genome Reveals a Reduced Innate Immune System.
Annotation of the Asian Citrus Psyllid Genome Reveals a Reduced Innate Immune System.
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DOI：
10.3389/fphys.2016.00570
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发表时间：
2016
影响因子：
4
通讯作者：
Pelz-Stelinski KS
中科院分区：
文献类型：
--
作者：
Arp AP;Hunter WB;Pelz-Stelinski KS
目前，世界范围内的柑橘生产因柑橘绿化病（也称为黄龙病）而面临重大损失。柑桔绿变菌（Citrus Liberibacter asiaticus，CLas）是由柑桔木虱Diaphorina citri Kuwayama传播的一种持续性繁殖病原菌。迄今为止，半翅目昆虫缺乏许多昆虫免疫基因，包括与革兰氏阴性菌靶向Imd途径相关的基因。地方citri基因组草图用于鉴定柑橘D.柑橘。通过筛选已发表的D.使用来自先前注释的昆虫基因组的免疫基因的定制数据库人工搜索Citri注释的基因组草图。Toll和JAK/STAT信号通路、一般防御基因Dual氧化酶、一氧化氮合酶、酚氧化酶原和细胞免疫防御基因等在D.柑橘。与此相反，D.柑橘缺乏Imd途径、大多数抗菌肽、1，3-β-葡聚糖识别蛋白（GNBP）和完整的肽聚糖识别蛋白的基因。这些数据表明D. Citri具有与在A. pisum、人疫霉（P. humanus）和人疫霉（R.冗长D.柑橘基因组可能促进CLas感染，并且可能通过它们与它们的微生物内共生体的关系来补偿。
Citrus production worldwide is currently facing significant losses due to citrus greening disease, also known as Huanglongbing. The citrus greening bacteria, Candidatus Liberibacter asiaticus (CLas), is a persistent propagative pathogen transmitted by the Asian citrus psyllid, Diaphorina citri Kuwayama (Hemiptera: Liviidae). Hemipterans characterized to date lack a number of insect immune genes, including those associated with the Imd pathway targeting Gram-negative bacteria. The D. citri draft genome was used to characterize the immune defense genes present in D. citri. Predicted mRNAs identified by screening the published D. citri annotated draft genome were manually searched using a custom database of immune genes from previously annotated insect genomes. Toll and JAK/STAT pathways, general defense genes Dual oxidase, Nitric oxide synthase, prophenoloxidase, and cellular immune defense genes were present in D. citri. In contrast, D. citri lacked genes for the Imd pathway, most antimicrobial peptides, 1,3-β-glucan recognition proteins (GNBPs), and complete peptidoglycan recognition proteins. These data suggest that D. citri has a reduced immune capability similar to that observed in A. pisum, P. humanus, and R. prolixus. The absence of immune system genes from the D. citri genome may facilitate CLas infections, and is possibly compensated for by their relationship with their microbial endosymbionts.
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DOI：
10.1673/031.013.12501
发表时间：
2013
期刊：
Journal of insect science (Online)
影响因子：
--
作者：
Arai I;Ohta M;Suzuki A;Tanaka S;Yoshizawa Y;Sato R
通讯作者：
Sato R
褐飞虱 Nilaparvata lugens 先天免疫的全基因组和转录组分析
影响因子：
4.4
作者：
Bao YY;Qu LY;Zhao D;Chen LB;Jin HY;Xu LM;Cheng JA;Zhang CX
通讯作者：
Zhang CX
影响因子：
1.4
作者：
Avery, Pasco B.;Hunter, Wayne B.;Rogers, Michael E.
通讯作者：
Rogers, Michael E.
影响因子：
5.4
作者：
Anselme C;Pérez-Brocal V;Vallier A;Vincent-Monegat C;Charif D;Latorre A;Moya A;Heddi A
通讯作者：
Heddi A
影响因子：
56.9
作者：
Christophides, GK;Zdobnov, E;Kafatos, FC
通讯作者：
Kafatos, FC