An analysis of the structural and functional similarities of insect hemocytes and mammalian phagocytes.
An analysis of the structural and functional similarities of insect hemocytes and mammalian phagocytes.
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DOI：
10.4161/viru.25906
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发表时间：
2013-10-01
期刊：
影响因子：
5.2
通讯作者：
Kavanagh K
中科院分区：
文献类型：
--
作者：
Browne N;Heelan M;Kavanagh K
昆虫的免疫应答与哺乳动物的先天免疫系统在结构和功能上有许多相似之处。由于这些保守的特征，昆虫已成为评价微生物病原体的毒力或评估抗微生物剂的功效的流行选择，并给出与使用哺乳动物可获得的结果相当的结果。对昆虫和哺乳动物免疫系统的细胞成分的分析表明了许多相似之处。昆虫血细胞识别病原体和吞噬物质的方式与中性粒细胞相似。在两种细胞类型中，通过产生超氧化物和通过在脱粒过程中释放酶来杀死摄入的微生物。昆虫血细胞和哺乳动物中性粒细胞对相同的抑制剂敏感。这篇综述强调了两组动物的吞噬细胞之间的强烈相似性，并证明了使用选定的昆虫作为体内筛选系统的潜在好处。
The insect immune response demonstrates a number of structural and functional similarities to the innate immune system of mammals. As a result of these conserved features insects have become popular choices for evaluating the virulence of microbial pathogens or for assessing the efficacy of antimicrobial agents and give results which are comparable to those that can be obtained using mammals. Analysis of the cellular component of the insect and mammalian immune systems demonstrates many similarities. Insect hemocytes recognize pathogens and phagocytose material in a similar manner to neutrophils. The killing of ingested microbes is achieved in both cell types by the production of superoxide and by the release of enzymes in the process of degranulation. Insect hemocytes and mammalian neutrophils are sensitive to the same inhibitors. This review highlights the strong similarities between the phagocytic cells of both groups of animals and demonstrates the potential benefits of using selected insects as in vivo screening systems.
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DOI：
10.1007/978-1-61779-539-8_33
发表时间：
2012-01-01
期刊：
Methods in molecular biology (Clifton, N.J.)
影响因子：
--
作者：
Fallon, John;Kelly, Judy;Kavanagh, Kevin
通讯作者：
Kavanagh, Kevin
影响因子：
5.4
作者：
Engering, AJ;Cella, M;Pieters, J
通讯作者：
Pieters, J
影响因子：
4.9
作者：
Hamamoto, H;Kurokawa, K;Sekimizu, K
通讯作者：
Sekimizu, K
影响因子：
5.8
作者：
Aperis, George;Fuchs, Beth Burgwyn;Mylonakis, Eleftherios
通讯作者：
Mylonakis, Eleftherios
影响因子：
2.8
作者：
Fallon, John P.;Reeves, Emer P.;Kavanagh, Kevin
通讯作者：
Kavanagh, Kevin