The Effects of Roux-en-Y Gastric Bypass on Glucose- vs. Fructose-Associated Conditioned Flavor Preference.
The Effects of Roux-en-Y Gastric Bypass on Glucose- vs. Fructose-Associated Conditioned Flavor Preference.
复制标题
roux-en-y胃旁路对葡萄糖与果糖相关的条件风味偏好的影响。
DOI：
10.1016/j.physbeh.2022.113730
复制
发表时间：
2022-05-01
影响因子：
2.9
通讯作者：
Spector AC
中科院分区：
文献类型：
--
作者：
Inui T;Inui-Yamamoto C;Schmid F;Blonde GD;Spector AC
在啮齿类动物中，反复单瓶暴露于具有不同风味的等热量葡萄糖和果糖溶液中，这两种糖具有不同的代谢途径，最终导致对前者的偏好。由于Roux-en-Y胃旁路术（RYGB）手术降低了大鼠对糖溶液的偏好和摄入量，我们测试了RYGB是否会减少对葡萄糖配对与果糖配对口味的偏好。RYGB（n=11;用一瓶含有0.05%葡萄或樱桃Kool-Aid调味的8%葡萄糖溶液（Glu/CSG）或含有替代Kool-Aid调味剂的8%果糖溶液（Fru/CSF）的单瓶（30分钟/天）以交替方式训练假手术（SHAM; SHAM =9; SHAM =10）大鼠8天。为了确定基线偏好，在训练前使用4天30分钟的两瓶测试来评估对Glu/CSG与Fru/CSF的偏好。训练后，2天30分钟的两瓶测试评估对a）Glu/CSG（CSG调味的8%葡萄糖溶液）相对于Fru/CSF（CSF调味的8%果糖溶液）的偏好，B）CSG-相对于CSF调味的4%葡萄糖和4%果糖的混合物（等热量），c）CSG-相对于CSF调味的0.2%糖精（“甜的”，无热量），和d）CSG-相对于CSF调味的水。在训练过程中，只有雄性SHAM大鼠表现出逐渐增加的摄入量的Glu/CSG的Fru/CSF，和雌性SHAM大鼠表现出的趋势。RYGB消除了培训期间这些溶液单瓶摄入量的任何差异，无论性别如何。像他们的男性和女性的SHAM同行，男性RYGB大鼠表现出条件偏好的CSG相关的刺激在测试1-3。在试验1中，雌性RYGB大鼠表现出条件性风味偏好的获得，但与其他组不同，在试验2和3中，当除去两种溶液之间的差异性糖提示时，雌性大鼠没有表现出CSG偏好。当糖和甜味剂的线索都被删除测试4，所有的群体表现出一定的泛化递减。因此，当在测试中呈现训练中使用的精确CS时，RYGB不损害大鼠学习和表达葡萄糖与果糖相关的条件性风味偏好的能力。RYGB对这种类型的风味偏好学习中观察到的概括减弱的影响存在性别差异的机制基础值得进一步研究。
In rodents, repeated single-bottle exposures to distinctly flavored isocaloric glucose and fructose solutions, two sugars with different metabolic pathways, eventually lead to a preference for the former. Because Roux-en-Y gastric bypass (RYGB) surgery decreases preference for and intake of sugar solutions in rats, we tested whether RYGB would curtail the conditioning of a preference for a glucose-paired vs. fructose-paired flavor. RYGB (♂ n=11; ♀ n=10) and sham-operated (SHAM; ♂ n=9; ♀ n=10) rats were trained with a single bottle (30 min/day) containing 8% glucose solution flavored with either 0.05% grape or cherry Kool-Aid (Glu/CSG) or 8% fructose solution with the alternative Kool-Aid flavor (Fru/CSF) in an alternating fashion for 8 days. To determine baseline preferences, a 4-day 30-min two-bottle test was used to assess preference for Glu/CSG vs. Fru/CSF before training. After training, 2-day 30-min two-bottle tests assessed preference for the a) Glu/CSG (CSG-flavored 8% glucose solution) vs Fru/CSF (CSF-flavored 8% fructose solution), b) CSG- vs. CSF-flavored mixture of 4% glucose & 4% fructose (isocaloric), c) CSG- vs. CSF-flavored 0.2% saccharin (“sweet”, no calories), and d) CSG- vs. CSF-flavored water. During training, only male SHAM rats demonstrated progressively increased intake of Glu/CSG over Fru/CSF, and female SHAM rats displayed a trend. RYGB eliminated any difference in single-bottle intake of these solutions during training, regardless of sex. Like their male and female SHAM counterparts, male RYGB rats displayed a conditioned preference for the CSG-associated stimulus in Tests 1-3. Although female RYGB rats displayed acquisition of the conditioned flavor preference in Test 1, unlike the other groups, when the differential sugar cue between the two solutions was removed in Tests 2 and 3, female rats did not display a CSG preference. When the sugar and sweetener cues were both removed on Test 4, all groups displayed some generalization decrement. Thus, RYGB does not compromise the ability of rats to learn and express a glucose- vs. fructose-associated conditioned flavor preference when the exact CS used in training is presented in testing. The mechanistic basis for the sex difference in the effect of RYGB on the generalization decrement observed in this type of flavor preference learning warrants further study.
登录
查看更多内容
影响因子：
29
作者：
Jang C;Hui S;Lu W;Cowan AJ;Morscher RJ;Lee G;Liu W;Tesz GJ;Birnbaum MJ;Rabinowitz JD
通讯作者：
Rabinowitz JD
影响因子：
8.8
作者：
Kapoor, Natasha;Al-Najim, Werd;Docherty, Neil G.
通讯作者：
Docherty, Neil G.
影响因子：
2.9
作者：
Ackroff, K;Touzani, K;Sclafani, A
通讯作者：
Sclafani, A
影响因子：
2.9
作者：
DRUCKER, DB;ACKROFF, K;SCLAFANI, A
通讯作者：
SCLAFANI, A
影响因子：
2.9
作者：
Hao Z;Mumphrey MB;Townsend RL;Morrison CD;Münzberg H;Ye J;Berthoud HR
通讯作者：
Berthoud HR