A case-control study of visual, auditory and audio-visual sensory interactions in children with autism spectrum disorder.
A case-control study of visual, auditory and audio-visual sensory interactions in children with autism spectrum disorder.
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DOI：
10.1167/jov.21.4.5
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发表时间：
2021-04-01
影响因子：
1.8
通讯作者：
Hardan AY
中科院分区：
文献类型：
--
作者：
Norcia AM;Lee A;Meredith WJ;Kohler PJ;Pei F;Ghassan SA;Libove RA;Phillips JM;Hardan AY
为了评估自闭症谱系障碍（ASD）早期视觉和听觉过程的相对完整性，我们在病例对照设计中使用了频率标记的视觉和听觉刺激以及单峰和双峰反应的高密度脑电图记录。为了测试对ASD影响的特异性，我们记录了一小群患有注意力缺陷多动障碍（ADHD）的儿童。水平3周期每度（cpd）光栅以5 Hz呈现，而/ba/， /da/， /ga/音节随机流以6 Hz呈现。光栅对比响应函数单模测量，并存在一个64分贝的听觉输入。听觉反应功能单模测量和40%的对比度光栅的存在。在视觉刺激频率的一次谐波测量中，与正常发育的儿童（n = 40）相比，患有ASD （n = 34）和ADHD （n = 13）的儿童普遍缺乏视听互动。两组患者在低对比下也表现出抑郁的第一谐波反应，但ADHD组在高对比下一贯表现出较高的第一谐波反应。ASD患儿有二次谐波（瞬态）反应优先丧失的特点。ASD中瞬时反应的改变很可能出现在视觉通路的早期，因此可能对许多其他视觉机制和过程产生下游影响。视听相互作用的改变可能是ASD和ADHD共有的共病表型的标志，可能是由于注意力选择系统的改变。
To assess the relative integrity of early visual and auditory processes in autism spectrum disorder (ASD), we used frequency-tagged visual and auditory stimulation and high-density electroencephalogram recordings of unimodal and dual-modality responses in a case–control design. To test for the specificity of effects on ASD, we recorded from a smaller group of children with attention-deficit hyperactivity disorder (ADHD). Horizontal 3 cycle per degree (cpd) gratings were presented at 5 Hz, and a random stream of /ba/, /da/, /ga/ syllables was presented at 6 Hz. Grating contrast response functions were measured unimodally and in the presence of a 64-dB auditory input. Auditory response functions were measured unimodally and in the presence of a 40% contrast grating. Children with ASD (n = 34) and ADHD (n = 13) showed a common lack of audio–visual interaction compared to typically developing children (n = 40) when measured at the first harmonic of the visual stimulus frequency. Both patient groups also showed depressed first harmonic responses at low contrast, but the ADHD group had consistently higher first-harmonic responses at high contrast. Children with ASD had a preferential loss of second-harmonic (transient) responses. The alteredtransient responses in ASD are likely to arise very early in the visual pathway and could thus have downstream consequences for many other visual mechanisms and processes. The alteration in audio–visual interaction could be a signature of a comorbid phenotype shared by ASD and ADHD, possibly due to alterations in attentional selection systems.
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影响因子：
6.7
作者：
Baum SH;Stevenson RA;Wallace MT
通讯作者：
Wallace MT
影响因子：
2.5
作者：
Cook E;Hammett ST;Larsson J
通讯作者：
Larsson J
影响因子：
2.9
作者：
Edgar JC;Lanza MR;Daina AB;Monroe JF;Khan SY;Blaskey L;Cannon KM;Jenkins J 3rd;Qasmieh S;Levy SE;Roberts TP
通讯作者：
Roberts TP
影响因子：
6.2
作者：
Edgar JC;Fisk Iv CL;Berman JI;Chudnovskaya D;Liu S;Pandey J;Herrington JD;Port RG;Schultz RT;Roberts TP
通讯作者：
Roberts TP
DOI：
10.1016/s0165-3806(03)00172-x
发表时间：
2003-09-10
期刊：
DEVELOPMENTAL BRAIN RESEARCH
影响因子：
--
作者：
Gage, NM;Siegel, B;Roberts, TPL
通讯作者：
Roberts, TPL