Color vision versus pattern visual evoked potentials in the assessment of subclinical optic pathway involvement in multiple sclerosis.
Color vision versus pattern visual evoked potentials in the assessment of subclinical optic pathway involvement in multiple sclerosis.
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DOI：
10.4103/0301-4738.99842
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发表时间：
2013-03
影响因子：
3.1
通讯作者：
Sobaci G
中科院分区：
文献类型：
--
作者：
Gundogan FC;Tas A;Altun S;Oz O;Erdem U;Sobaci G
多发性硬化症的视路受累通常是疾病过程中的初始体征。在大多数临床应用中，图形视觉诱发电位（PVEP）用于评估视路受累。探讨PVEP与色觉检查在亚临床视路受累诊断中的价值。这项前瞻性横断面研究包括20名无视神经炎病史的多发性硬化症患者和20名健康对照受试者。通过使用Roland-Consult RetiScan®系统进行Farnsm-Munsell（FM）100-Hue测试和PVEP到60分钟弧和15分钟弧检查。记录PVEP的P100波幅、P100潜伏期和FM 100-Hue测试的总错误分数（TES）。扩展残疾状态量表评分为2.21 ± 2.53（0 ~ 7）分，诊断时间为4.1 ± 4.4年。MS组P100潜伏期明显延长（P < 0.001）。同样，MS患者在FM-100 Hue中的总错误评分（TES）显著增加（P < 0.001）。TES与PVEP振幅/波幅之间的相关性在两项检查中均不显著（P > 0.05）。14例MS患者（70%）在FM-100 Hue中出现TES增加，11例（55%）MS患者出现P100潜伏期延迟，9例（45%）MS患者出现P100振幅降低。FM-100 Hue、P100潜伏期和P100波幅的ROC曲线下面积分别为0.944、0.753和0.173。色觉检查在检测MS亚临床视觉通路受累方面似乎比PVEP更敏感。
Optic pathway involvement in multiple sclerosis is frequently the initial sign in the disease process. In most clinical applications, pattern visual evoked potential (PVEP) is used in the assessment of optic pathway involvement. To question the value of PVEP against color vision assessment in the diagnosis of subclinical optic pathway involvement. This prospective, cross-sectional study included 20 multiple sclerosis patients without a history of optic neuritis, and 20 healthy control subjects. Farnsworth-Munsell (FM) 100-Hue testing and PVEPs to 60-min arc and 15-min arc checks by using Roland-Consult RetiScan® system were performed. P100 amplitude, P100 latency in PVEP and total error scores (TES) in FM 100-Hue test were assessed. Expanded Disability Status Scale score and the time from diagnosis were 2.21 ± 2.53 (ranging from 0 to 7) and 4.1 ± 4.4 years. MS group showed significantly delayed P100 latency for both checks (P < 0.001). Similarly, MS patients had significantly increased total error scores (TES) in FM-100 Hue (P < 0.001). The correlations between TESs and PVEP amplitudes / latencies were insignificant for both checks (P > 0.05 for all). 14 MS patients (70%) had an increased TESs in FM-100 Hue, 11 (55%) MS patients had delayed P100 latency and 9 (45%) had reduced P100 amplitude. The areas under the ROC curves were 0.944 for FM-100 Hue test, 0.753 for P100 latency, and 0.173 for P100 amplitude. Color vision testing seems to be more sensitive than PVEP in detecting subclinical visual pathway involvement in MS.
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影响因子：
4.4
作者：
Gundogan, Fatih C.;Demirkaya, Seref;Sobaci, Gungor
通讯作者：
Sobaci, Gungor
影响因子：
9.9
作者：
Sorensen, TL;Frederiksen, JL;Petersen, HC
通讯作者：
Petersen, HC
影响因子：
3
作者：
COUPLAND, SG;KIRKHAM, TH
通讯作者：
KIRKHAM, TH
影响因子：
9.9
作者：
KUPERSMITH, MJ;NELSON, JI;WEISS, PA
通讯作者：
WEISS, PA
影响因子：
1.9
作者：
VANDIEMEN, HAM;LANTING, P;POLMAN, CH
通讯作者：
POLMAN, CH