Photoacoustic imaging of squirrel monkey cortical and subcortical brain regions during peripheral electrical stimulation.
Photoacoustic imaging of squirrel monkey cortical and subcortical brain regions during peripheral electrical stimulation.
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DOI：
10.1016/j.pacs.2021.100326
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发表时间：
2022-03
期刊：
影响因子：
7.9
通讯作者：
Wang X
中科院分区：
文献类型：
--
作者：
Chang KW;Zhu Y;Hudson HM;Barbay S;Guggenmos DJ;Nudo RJ;Yang X;Wang X
非人灵长类动物模型中神经元活动的研究是至关重要的，因为它们与人类大脑的遗传相似性。在这项研究中，我们测试的可行性，使用光声成像检测皮层和皮层下的反应，由于外周电刺激的松鼠猴模型。应用光声计算机断层扫描和光声显微镜对松鼠猴进行实时深层皮层下成像和光学分辨率皮层成像。电诱发血流动力学的变化，主要躯体感觉皮层，运动前皮层，初级运动皮层，和下面的皮层下区进行了测量。在外部刺激过程中，观察到皮质和皮质下脑区的血流动力学反应，证明了光声技术用于非人灵长类动物脑功能成像的可行性。
The investigation of neuronal activity in non-human primate models is of critical importance due to their genetic similarity to human brains. In this study, we tested the feasibility of using photoacoustic imaging for the detection of cortical and subcortical responses due to peripheral electrical stimulation in a squirrel monkey model. Photoacoustic computed tomography and photoacoustic microscopy were applied on squirrel monkeys for real-time deep subcortical imaging and optical-resolution cortical imaging, respectively. The electrically evoked hemodynamic changes in primary somatosensory cortex, premotor cortices, primary motor cortex, and underlying subcortical areas were measured. Hemodynamic responses were observed in both cortical and subcortical brain areas at the cortices during external stimulation, demonstrating the feasibility of photoacoustic technique for functional imaging of non-human primate brain.
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影响因子：
3.5
作者：
Jones, Phill B.;Shin, Hwa Kyoung;Dunn, Andrew K.
通讯作者：
Dunn, Andrew K.
血液氧合的光声断层扫描：迷你综述。
影响因子：
7.9
作者：
Li M;Tang Y;Yao J
通讯作者：
Yao J
DOI：
10.1073/pnas.88.24.11559
发表时间：
1991-12-01
影响因子：
11.1
作者：
GRINVALD, A;FROSTIG, RD;BARTFELD, E
通讯作者：
BARTFELD, E
DOI：
10.1097/00004647-200405000-00005
发表时间：
2004-05-01
影响因子：
6.3
作者：
Durduran, T;Burnett, MG;Greenberg, JH
通讯作者：
Greenberg, JH
影响因子：
4.8
作者：
Gamlin, PD;Ward, MK;Twieg, DB
通讯作者：
Twieg, DB