Associations between regular cannabis use and brain resting-state functional connectivity in adolescents and adults
Associations between regular cannabis use and brain resting-state functional connectivity in adolescents and adults
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青少年和成人定期使用大麻与大脑静息状态功能连接之间的关联
DOI：
10.1101/2022.08.24.505069
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Ertl N
中科院分区：
文献类型：
--
作者：
Ertl N
背景/目的大麻的使用在青少年中非常普遍；然而，人们对它对青少年大脑功能的影响知之甚少。方法采用睡眠状态功能磁共振成像技术，将正常吸食大麻人群（16-17岁青少年70 35人，成人26-29岁35人）和非正常吸食大麻人群（青少年35人/成人35人）进行配对。预先注册的分析使用基于种子的分析方法，对用户组和年龄组之间的横断面比较，检查了七个主要皮层和皮层下大脑网络（默认模式网络、执行控制网络（ECN）、显著性网络、海马网络和三个纹状体网络）的连通性。结果：与对照组相比，经常使用大麻的组（跨越两个年龄组）仅在ECN分析中显示出局部连通性的增加。所有网络都显示出基于年龄组的局部连通性差异，青少年普遍表现出比成年人更弱的连通性，这与发育效应相一致。青少年ECN中整个感兴趣网络区域（roi）的平均连通性也显著降低。然而，在任何基于种子或ROI的分析中，都没有发现年龄组和用户组之间的显著相互作用。也没有发现大麻使用频率与任何衍生的连通性指标之间的关联。结论经常使用大麻与ECN连通性的变化有关，这可能反映了对定期大麻中毒的适应或代偿性变化。然而，与成年人相比，这些关联在青少年中没有显著差异。
Background/aimCannabis use is highly prevalent in adolescents; however, little is known about its effects on adolescent brain function.MethodResting-state functional magnetic resonance imaging was used in matched groups of regular cannabis users (N= 70, 35 adolescents: 16–17 years old, 35 adults: 26–29 years old) and non-regular-using controls (N= 70, 35 adolescents/35 adults). Pre-registered analyses examined the connectivity of seven major cortical and sub-cortical brain networks (default mode network, executive control network (ECN), salience network, hippocampal network and three striatal networks) using seed-based analysis methods with cross-sectional comparisons between user groups and age groups.ResultsThe regular cannabis use group (across both age groups), relative to controls, showed localised increases in connectivity only in the ECN analysis. All networks showed localised connectivity differences based on age group, with the adolescents generally showing weaker connectivity than adults, consistent with the developmental effects. Mean connectivity across entire network regions of interest (ROIs) was also significantly decreased in the ECN in adolescents. However, there were no significant interactions found between age group and user group in any of the seed-based or ROI analyses. There were also no associations found between cannabis use frequency and any of the derived connectivity measures.ConclusionRegular cannabis use is associated with changes in connectivity of the ECN, which may reflect allostatic or compensatory changes in response to regular cannabis intoxication. However, these associations were not significantly different in adolescents compared to adults.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
DOI：
10.1016/0165-3806(95)00109-q
发表时间：
1995-11-21
期刊：
DEVELOPMENTAL BRAIN RESEARCH
影响因子：
--
作者：
TEICHER, MH;ANDERSEN, SL;HOSTETTER, JC
通讯作者：
HOSTETTER, JC
影响因子：
8.2
作者：
Blest-Hopley G;Giampietro V;Bhattacharyya S
通讯作者：
Bhattacharyya S
影响因子：
1.7
作者：
DEFONSECA, FR;RAMOS, JA;FERNANDEZRUIZ, JJ
通讯作者：
FERNANDEZRUIZ, JJ
大麻的历史
DOI：
10.1007/978-3-030-69186-8_1
发表时间：
2021
期刊：
Cannabinoids and Pain
影响因子：
--
作者：
A. Shustorovich;S. Narouze
通讯作者：
S. Narouze