Neuroanatomical correlates of dysglycemia in young children with type 1 diabetes.
Neuroanatomical correlates of dysglycemia in young children with type 1 diabetes.
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DOI：
10.2337/db13-0179
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发表时间：
2014-01
期刊：
影响因子：
7.7
通讯作者：
Diabetes Research in Children Network (DirecNet)
中科院分区：
文献类型：
--
作者：
Marzelli MJ;Mazaika PK;Barnea-Goraly N;Hershey T;Tsalikian E;Tamborlane W;Mauras N;White NH;Buckingham B;Beck RW;Ruedy KJ;Kollman C;Cheng P;Reiss AL;Diabetes Research in Children Network (DirecNet)
对1型糖尿病(T1D)脑结构的研究描述了与成人和青少年血糖调节失调相关的广泛的神经解剖学差异。在这项研究中，我们调查了早发性T1D儿童血糖异常的神经解剖学相关性。对142例T1D儿童和68例年龄匹配的正常儿童(平均年龄7.0±1.7岁)在6台相同的扫描仪上进行了脑结构磁共振成像。使用基于体素的形态计量学进行全脑体积分析，以检测不同组之间的区域差异，并调查区域脑体积与血糖暴露指标(包括来自连续血糖监测的数据)之间的相关性。与对照组相比，T1D组双侧枕叶和小脑区灰质体积减小(P<；0.001)，左侧前额下部、脑岛和颞极区灰质体积增大(P=0.002)。在T1D组中，高血糖暴露与额叶内侧和颞枕区域的GMV降低和额叶外侧区域的GMV增加相关。正如预期的那样，对照组的小脑-枕区和内侧前额叶皮质存在智商与GMV的认知相关，而T1D组则没有。因此，早发性T1D会影响大脑中与典型认知发育相关的区域。
Studies of brain structure in type 1 diabetes (T1D) describe widespread neuroanatomical differences related to exposure to glycemic dysregulation in adults and adolescents. In this study, we investigate the neuroanatomical correlates of dysglycemia in very young children with early-onset T1D. Structural magnetic resonance images of the brain were acquired in 142 children with T1D and 68 age-matched control subjects (mean age 7.0 ± 1.7 years) on six identical scanners. Whole-brain volumetric analyses were conducted using voxel-based morphometry to detect regional differences between groups and to investigate correlations between regional brain volumes and measures of glycemic exposure (including data from continuous glucose monitoring). Relative to control subjects, the T1D group displayed decreased gray matter volume (GMV) in bilateral occipital and cerebellar regions (P < 0.001) and increased GMV in the left inferior prefrontal, insula, and temporal pole regions (P = 0.002). Within the T1D group, hyperglycemic exposure was associated with decreased GMV in medial frontal and temporal-occipital regions and increased GMV in lateral prefrontal regions. Cognitive correlations of intelligence quotient to GMV were found in cerebellar-occipital regions and medial prefrontal cortex for control subjects, as expected, but not for the T1D group. Thus, early-onset T1D affects regions of the brain that are associated with typical cognitive development.
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影响因子：
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作者：
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