Physical activity and risks of esophageal and gastric cancers: a meta-analysis.
Physical activity and risks of esophageal and gastric cancers: a meta-analysis.
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DOI：
10.1371/journal.pone.0088082
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Li Y
中科院分区：
文献类型：
--
作者：
Chen Y;Yu C;Li Y
近年来，食管癌和胃癌的发病率在世界范围内迅速上升，但其原因尚不清楚。在这里，对评估体育活动（众所周知的预防死亡和其他慢性疾病的保护因素）与食管癌和胃癌风险之间关系的研究进行了统计综合。使用Medline和Embase确定可能合适的研究。人工检索了所有纳入文章的参考文献列表和最近几篇综述的参考文献列表。纳入以下研究：(1)发表为病例对照或队列研究，评估体育活动与食管癌或胃癌风险之间的关系；(2)体力活动与食管癌或胃癌风险的报告点估计（即风险比、优势比）和变异性测量（即95%置信区间[ci]）。纳入了15项研究（7个队列，8个病例对照，984例食管癌和7087例胃癌）。总的来说，他们表明，最活跃的人患胃癌的风险比最不活跃的人低13% (RR = 0.87, 95%可信区间[CI] = 0.78至0.97)，食管癌的风险低27% （RR = 0.73, 95% CI = 0.56至0.97）。观察性研究的综合结果支持体育锻炼对食管癌和胃癌的保护作用。
The incidence of esophageal and gastric cancer has been increasing rapidly worldwide in recent years, although the reason for this increase is unclear. Here, a statistical synthesis of studies that evaluated the association between physical activity, a well-known protecting factor against death and other chronic diseases, and the risk of esophageal and gastric cancer was performed. Potentially suitable studies were identified using Medline and Embase. The reference lists of all included articles and those of several recent reviews were searched manually. Studies were included if they (1) were published as case-control or cohort studies evaluating the association between physical activity and risk of esophageal or gastric cancer; and (2) reported point estimates (i.e., risk ratios, odds ratios) and measures of variability (i.e., 95% confidence intervals [CIs]) for physical activity and risk of esophageal or gastric cancer. Fifteen studies were identified (7 cohorts, 8 case-controls; 984 esophageal and 7,087 gastric cancers). Collectively, they indicated that the risk of gastric cancer was 13% lower among the most physically active people than among the least active people (RR = 0.87, 95% confidence interval [CI] = 0.78 to 0.97) and that of esophageal cancer was 27% lower (RR = 0.73, 95% CI = 0.56 to 0.97). Pooled results from observational studies support a protective effect of physical activity against both esophageal and gastric cancer.
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