Selective antibody transport in the proximal small intestine of the neonatal rat.
Selective antibody transport in the proximal small intestine of the neonatal rat.
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DOI：
10.1083/jcb.45.3.635
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发表时间：
1970-06
期刊：
影响因子：
--
通讯作者：
Rodewald R
中科院分区：
文献类型：
--
作者：
Rodewald R
许多生理学研究已经证明了新生大鼠小肠中抗体转运的高度选择性（HaUiday，1955，1958; Bangham和Terry，1957; Halliday和Kekwick，1960; Jordan和Morgan，1968）。大鼠的IgG抗体可以在功能上不改变地大量从肠腔转移到循环中，而其它乳和血清蛋白以小得多的量或根本不被转移。最近，研究人员提出，选择性抗体转运发生在小肠远端区域的上皮细胞。然而，据我们所知，文献中没有报道比较肠近端和远端部分中抗体转运的实验，尽管许多研究强调了明显的形态学差异（Clark，1959; Graney，1968）和生理学差异（Clark，1959; Koldovsk和Chytil，1965; Heringovfi等人，1965; Noack等人，1966年，在这些地区。因此，我们决定确定这些区域之间在转运抗体的能力上是否存在类似的差异。本文报道的一个简单的结扎实验表明，大部分选择性抗体转运发生在近三分之一的肠道。在第二个实验中，将近端区域的组织暴露于与fcrltin偶联的免疫球蛋白，随后用电子显微镜研究选择的形态学基础和抗体穿过上皮细胞的运输。
Numerous physiological studies have demonstratcd the highly selective nature of antibody transport in the small intestine of the neonatal rat (HaUiday, 1955, 1958; Bangham and Terry, 1957; Halliday and Kekwick, 1960; Jordan and Morgan, 1968).-it G antibodies of the rat can be transferred functionally unaltered in large quantities from the lumen of the intestine into the circulation, whereas other milk and serum proteins arc transported in much smaller quantities or not at all. Recently investigators have proposed that selective antibody transport occurs across the epithelial cells in the distal region of the small intestine. However, to our knowledge no experiments have been reported in the literature which compare antibody transport in the proximal and distal portions of the intestine, even though many studies have emphasized marked morphological (Clark, 1959; Graney, 1968) and physiological differences (Clark, 1959; Koldovsk~ and Chytil, 1965; Heringovfi et al., 1965; Noack et al., 1966) between these regions. We decided, therefore, to determine whether a difference similarly exists between these regions in their ability to transport antibodies. A simple ligation experiment reported in this paper indicates that the bulk of selective antibody transport occurs in the proximal onethird of the intestine. In a second experiment, tissue in the proximal region was exposed to immunoglobulin conjugated to fcrrltin which could bc followed with the electron microscope to study the morphological basis of selection and transport of antibodies across the epithelial cells.
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DOI：
10.1098/rspb.1966.0083
发表时间：
1966-01-01
期刊：
PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES
影响因子：
--
作者：
BAMFORD, DR
通讯作者：
BAMFORD, DR
DOI：
10.1098/rspb.1958.0046
发表时间：
1958-01-01
期刊：
PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES
影响因子：
--
作者：
BRAMBELL, FWR;HALLIDAY, R;MORRIS, IG
通讯作者：
MORRIS, IG
DOI：
10.1098/rspb.1958.0008
发表时间：
1958-01-01
期刊：
PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES
影响因子：
--
作者：
HALLIDAY, R
通讯作者：
HALLIDAY, R
DOI：
10.1139/o65-024
发表时间：
1965-01-01
期刊：
CANADIAN JOURNAL OF BIOCHEMISTRY
影响因子：
--
作者：
HERINGOVA, A;JIRSOVA, V;KOLDOVSKY, O
通讯作者：
KOLDOVSKY, O
影响因子：
168.9
作者：
BRAMBELL, FW
通讯作者：
BRAMBELL, FW