Effects of electronic cigarette liquid solvents propylene glycol and vegetable glycerin on user nicotine delivery, heart rate, subjective effects, and puff topography.
Effects of electronic cigarette liquid solvents propylene glycol and vegetable glycerin on user nicotine delivery, heart rate, subjective effects, and puff topography.
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DOI：
10.1016/j.drugalcdep.2018.03.042
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发表时间：
2018-07-01
影响因子：
4.2
通讯作者：
Eissenberg T
中科院分区：
文献类型：
--
作者：
Spindle TR;Talih S;Hiler MM;Karaoghlanian N;Halquist MS;Breland AB;Shihadeh A;Eissenberg T
电子烟 (ECIG) 是一类烟草产品，会根据设备、液体和行为因素产生不同的效果（例如尼古丁释放）。然而，两种主要 ECIG 液体溶剂丙二醇 (PG) 和植物甘油 (VG) 对 ECIG 急性效应的影响尚不清楚。 30 名有 ECIG 经验、戒烟 12 小时以上的参与者完成了四种条件，包括两次 ECIG 使用回合（10 口，30 秒的抽吸间隔），仅液体 PG:VG 比例不同（2PG:98VG、20PG:80VG、55PG:45VG、100PG）。设备功率（7.3 W）和液体尼古丁浓度（18 mg/ml）保持恒定。评估了尼古丁输送、主观效果、心率 (HR) 和抽吸地形。在 100PG 条件下，参与者吸的时间更短、更小，但相对于两种基于 VG 的条件，获得的尼古丁明显更多。在使用两种 PG 液体期间，总尼古丁暴露量（即曲线下面积）也显着更高。然而，参与者报告说，相对于其他液体（所有 ps < .05），100 PG 液体明显不太“令人愉快”和“令人满意”。 HR 的增加和戒断症状（例如“渴望”）的减少在不同条件下没有差异。 PG:VG 比例影响尼古丁释放、一些主观效果和抽吸形态。与 100PG 液体相关的总体产品满意度较低表明尼古丁输送以外的因素（例如气溶胶可见度）可能在维持 ECIG 使用方面发挥作用。调节 ECIG 急性效应（例如尼古丁输送和主观效应）可能需要同时关注液体 PG:VG 比例以及已知影响这些结果的设备、液体和行为因素。
Electronic cigarettes (ECIGs) are a class of tobacco products that produce different effects (e.g., nicotine delivery), depending on the device, liquid, and behavioral factors. However, the influence of the two primary ECIG liquid solvents, propylene glycol (PG) and vegetable glycerin (VG), on ECIG acute effects is unknown. Thirty ECIG-experienced, ≥ 12-h nicotine- abstinent participants completed four conditions consisting of two ECIG-use bouts (10 puffs, 30 s interpuff-interval) differing only by liquid PG:VG ratio (2PG:98VG, 20PG:80VG, 55PG:45VG, 100PG). Device power (7.3 W) and liquid nicotine concentration (18 mg/ml) remained constant. Nicotine delivery, subjective effects, heart rate (HR), and puff topography were assessed. In the 100PG condition, participants took shorter and smaller puffs but obtained significantly more nicotine relative to the two VG-based conditions. Total nicotine exposure (i.e., area under the curve) was also significantly higher during use of the two PG-based liquids. However, participants reported that the 100 PG liquid was significantly less “pleasant” and “satisfying” relative to the other liquids (all ps < .05). Increases in HR and decreases in abstinence symptoms (e.g., “craving”) did not differ across conditions. PG:VG ratio influenced nicotine delivery, some subjective effects, and puff topography. Lower overall product satisfaction associated with the 100PG liquid suggests factors other than nicotine delivery (e.g., aerosol visibility) may play a role in maintaining ECIG use. Regulating ECIG acute effects such as nicotine delivery and subjective effects may require simultaneous attention to liquid PG:VG ratio as well as device, liquid, and behavioral factors known to influence these outcomes.
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影响因子：
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