Choroidal Biomarkers: A Repeatability and Topographical Comparison of Choroidal Thickness and Choroidal Vascularity Index in Healthy Eyes.
Choroidal Biomarkers: A Repeatability and Topographical Comparison of Choroidal Thickness and Choroidal Vascularity Index in Healthy Eyes.
复制标题
DOI：
10.1167/tvst.9.11.8
复制
发表时间：
2020-10
影响因子：
3
通讯作者：
Wahl S
中科院分区：
文献类型：
--
作者：
Breher K;Terry L;Bower T;Wahl S
脉络膜厚度（ChT）和脉络膜血管指数（CVI）代表了健康、疾病和近视相关研究中的两个重要指标。宽视场扫频光源光学相干断层扫描（OCT）提供了改进和扩展的成像和提取脉络膜变量。这项研究的特点，在健康的眼睛，这些参数的地形和可重复性。扫描源OCT体积扫描获得了14名年轻的成年患者在三个不同的日子。ChT和CVI自动校正图像放大率，并在10 mm直径的扩展ETDRS网格内提取不同的表面区域。地形分布，相关的眼球长度，和会话间的重复性两个脉络膜参数进行了评估。与ChT不同，CVI显示子场之间的波动很小，ChT显示向外周脉络膜变薄（变异系数为5.92 vs. 0.89）。ChT与眼轴长度呈一致的负相关（ρ = −0.05至−0.61），尽管这仅在内部上级子区具有统计学显著性（P = 0.02）。CVI和眼轴长度之间或CVI和ChT之间没有一致或显著的关系。扫描区域之间CVI测量值的重复性（3.90%-5.51%）比ChT测量值（10.37-20.33 µm）更一致。CVI值是一致的整个中央10毫米的视网膜，而ChT减少偏心。这两个参数的重复性与许多使用脉络膜作为生物标志物的研究中报告的效应量相似，在解释结果时应考虑这一点。本研究为ChT和CVI在健康和疾病中的临床解释提供了规范性和可重复性信息。
Choroidal thickness (ChT) and choroidal vascularity index (CVI) represent two important metrics in health-, disease-, and myopia-related studies. Wide-field swept-source optical coherence tomography (OCT) provides improved and extended imaging and extraction of choroidal variables. This study characterizes the topography and repeatability of these parameters in healthy eyes. Swept-source OCT volume scans were obtained on 14 young adult patients on three separate days. ChT and CVI were automatically corrected for image magnification and extracted for different enface regions within an extended ETDRS grid of 10 mm diameter. Topographical distribution, correlation to ocular length, and intersession repeatability of both choroidal parameters were assessed. CVI showed little fluctuation between subfields, unlike ChT, which demonstrated thinning toward the peripheral choroid (coefficients of variation 5.92 vs. 0.89). ChT showed a consistent negative correlation with axial length (ρ = −0.05 to −0.61), although this was only statistically significant in the inner superior subfield (P = 0.02). There was no consistent or significant relationship between CVI and axial length or between CVI and ChT. The repeatability of CVI measurements (3.90%–5.51%) was more consistent between scan regions than ChT measurements (10.37–20.33 µm). CVI values were consistent across the central 10 mm of the retina, while ChT reduced with eccentricity. The repeatability of both parameters is similar to the effect size reported in many studies using the choroid as a biomarker, which should be considered in the interpretation of findings. This study provided normative as well as metrological information for the clinical interpretation of ChT and CVI in health and disease.
登录
查看更多内容
影响因子：
3
作者：
Kong M;Choi DY;Han G;Song YM;Park SY;Sung J;Hwang S;Ham DI
通讯作者：
Ham DI
影响因子：
2.3
作者：
Alshareef RA;Khuthaila MK;Januwada M;Goud A;Ferrara D;Chhablani J
通讯作者：
Chhablani J
扫频光学相干断层扫描测量不同屈光状态儿童的脉络膜和视网膜厚度
影响因子：
4.2
作者：
Jin, Peiyao;Zou, Haidong;He, Xiangui
通讯作者：
He, Xiangui
影响因子：
3.4
作者：
Agrawal, Rupesh;Wei, Xin;Chhablani, Jay
通讯作者：
Chhablani, Jay
影响因子：
3.2
作者：
Li, Zhouyue;Cui, Dongmei;Yang, Xiao
通讯作者：
Yang, Xiao