Association of FTO with obesity-related traits in the Cebu Longitudinal Health and Nutrition Survey (CLHNS) Cohort.
Association of FTO with obesity-related traits in the Cebu Longitudinal Health and Nutrition Survey (CLHNS) Cohort.
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DOI：
10.2337/db07-1700
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发表时间：
2008-07
期刊：
影响因子：
7.7
通讯作者：
Mohlke, Karen L.
中科院分区：
文献类型：
--
作者：
Marvelle, Amanda F.;Lange, Leslie A.;Qin, Li;Adair, Linda S.;Mohlke, Karen L.
目的-肥胖相关性状的潜在遗传成分尚未被很好地理解，而且支持在多项研究、人群和环境背景下存在遗传关联的证据有限。本研究调查了来自宿务纵向健康和营养调查(CLHNS)队列的1886名菲律宾成年女性样本中候选变异与肥胖相关特征之间的关系。研究设计和方法-我们选择了10个基因(ADRB2、ADRB3、FTO、GNB3、INSIG2、LEPR、PPARG、肿瘤坏死因子、UCP2和UCP3)的19个单核苷酸多态，并对其进行了基因分型。结果：我们观察到rs9939609(FTO内含子1)的A等位基因与体重指数增加(多次测试校正前P=0.0072)、基线体重指数(P=0.0015)、纵向体重指数(P=0.000029)、腰围(P=0.0094)和体重(P=0.021)相关。每增加一个A等位基因，平均体重指数增加∼为0.4%。我们还观察到ADRB3Trp64Arg变异与BMI、腰围、体脂百分比、体重、脂肪质量、手臂脂肪面积和手臂肌肉面积之间的关联(P<；0.05)，尽管影响的方向与以前的大多数报告不一致。结论-我们的研究证实FTO是菲律宾人常见的肥胖易感基因，其影响大小与欧洲起源的样本中看到的相似。
OBJECTIVE—The underlying genetic component of obesity-related traits is not well understood, and there is limited evidence to support genetic association shared across multiple studies, populations, and environmental contexts. The present study investigated the association between candidate variants and obesity-related traits in a sample of 1,886 adult Filipino women from the Cebu Longitudinal Health and Nutrition Survey (CLHNS) cohort. RESEARCH DESIGN AND METHODS—We selected and genotyped 19 single nucleotide polymorphisms in 10 genes (ADRB2, ADRB3, FTO, GNB3, INSIG2, LEPR, PPARG, TNF, UCP2, and UCP3) that had been previously reported to be associated with an obesity-related quantitative trait. RESULTS—We observed evidence for association of the A allele of rs9939609 (FTO intron 1) with increased BMI (P = 0.0072 before multiple test correction), baseline BMI (P = 0.0015), longitudinal BMI based on eight surveys from 1983 to 2005 (P = 0.000029), waist circumference (P = 0.0094), and weight (P = 0.021). The increase in average BMI was ∼0.4 for each additional A allele. We also observed association of the ADRB3 Trp64Arg variant with BMI, waist circumference, percent body fat, weight, fat mass, arm fat area, and arm muscle area (P < 0.05), although the direction of effect is inconsistent with the majority of previous reports. CONCLUSIONS—Our study confirms that FTO is a common obesity susceptibility gene in Filipinos, with an effect size similar to that seen in samples of European origin.
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影响因子：
5.8
作者：
Fujisawa, T;Ikegami, H;Ogihara, T
通讯作者：
Ogihara, T
影响因子：
4.9
作者：
Smith, A. J. P.;Cooper, J. A.;Humphries, S. E.
通讯作者：
Humphries, S. E.
影响因子：
56.9
作者：
Frayling, Timothy M.;Timpson, Nicholas J.;McCarthy, Mark I.
通讯作者：
McCarthy, Mark I.
DOI：
10.1038/oby.2001.102
发表时间：
2001-12-01
期刊：
OBESITY RESEARCH
影响因子：
--
作者：
Kurokawa, N;Nakai, K;Satoh, H
通讯作者：
Satoh, H
影响因子：
56.9
作者：
Herbert, A;Gerry, NP;Christman, MF
通讯作者：
Christman, MF