Estimating Representative Group Intrinsic Circadian Period from Illuminance-Response Curve Data.
Estimating Representative Group Intrinsic Circadian Period from Illuminance-Response Curve Data.
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DOI：
10.1177/0748730419886992
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发表时间：
2020-04
影响因子：
3.5
通讯作者：
Diniz Behn, Cecilia
中科院分区：
文献类型：
--
作者：
Stack, Nora;Zeitzer, Jamie M.;Czeisler, Charles;Diniz Behn, Cecilia
人类的昼夜节律起搏器是24小时一天的，但个体间起搏器特性的差异，如内在周期，会影响时型和对昼夜节律系统挑战的中间反应，如轮班工作和时差，以及治疗干预措施的有效性，如光疗。昼夜节律特性的稳健表征要求昼夜节律系统与静息-活动周期去同步，而这些强制去同步协议是非常耗时和资源的。然而，设计用于推导光强度和相移之间的关系的昼夜节律方案可能会得到更广泛的应用，因为光强度和相移内在地受到固有周期的影响。为了利用这种关系，我们应用了人体昼夜节律起搏器的数学模型和马尔可夫链蒙特卡罗参数估计算法，利用一组参与者的集体照度-响应曲线数据来估计具有代表性的群体固有周期。我们首先使用已知固有周期的模拟照度-响应曲线数据来验证该方法。在内在周期的生理范围内，该方法准确地估计了群体具有代表性的内在周期。我们还将该方法应用于之前发表的描述一组健康成年参与者的照度-响应曲线的实验数据。我们使用统一的和正常的先验分别估计研究参与者的代表性群体的内在周期为24.26和24.27小时，这与使用强制去同步法确定的健康成年人的平均内在周期的估计一致。我们的结果建立了一种从照度-响应曲线数据中估计群体的代表性固有周期的方法，从而促进了比使用强制去同步协议所能研究的更广泛的参与者群体的内在周期的表征。未来这一方法的应用可能会提高对内在昼夜节律时期人口统计学差异的理解。
The human circadian pacemaker entrains to the 24-h day, but interindividual differences in properties of the pacemaker, such as intrinsic period, affect chronotype and mediate responses to challenges to the circadian system, such as shift work and jet lag, and the efficacy of therapeutic interventions such as light therapy. Robust characterization of circadian properties requires desynchronization of the circadian system from the rest-activity cycle, and these forced desynchrony protocols are very time and resource intensive. However, circadian protocols designed to derive the relationship between light intensity and phase shift, which is inherently affected by intrinsic period, may be applied more broadly. To exploit this relationship, we applied a mathematical model of the human circadian pacemaker with a Markov-Chain Monte Carlo parameter estimation algorithm to estimate the representative group intrinsic period for a group of participants using their collective illuminance-response curve data. We first validated this methodology using simulated illuminance-response curve data in which the intrinsic period was known. Over a physiological range of intrinsic periods, this method accurately estimated the representative intrinsic period of the group. We also applied the method to previously published experimental data describing the illuminance-response curve for a group of healthy adult participants. We estimated the study participants’ representative group intrinsic period to be 24.26 and 24.27 h using uniform and normal priors, respectively, consistent with estimates of the average intrinsic period of healthy adults determined using forced desynchrony protocols. Our results establish an approach to estimate a population’s representative intrinsic period from illuminance-response curve data, thereby facilitating the characterization of intrinsic period across a broader range of participant populations than could be studied using forced desynchrony protocols. Future applications of this approach may improve the understanding of demographic differences in the intrinsic circadian period.
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影响因子：
5.8
作者：
Crowley, Stephanie J.;Cain, Sean W.;Carskadon, Mary A.
通讯作者：
Carskadon, Mary A.
DOI：
10.1196/annals.1308.032
发表时间：
2004-01-01
期刊：
ADOLESCENT BRAIN DEVELOPMENT: VULNERABILITIES AND OPPORTUNITIES
影响因子：
--
作者：
Carskadon, MA;Acebo, C;Jenni, OG
通讯作者：
Jenni, OG
DOI：
10.1073/pnas.1010666108
发表时间：
2011-09-13
影响因子：
11.1
作者：
Duffy, Jeanne F.;Cain, Sean W.;Czeisler, Charles A.
通讯作者：
Czeisler, Charles A.
影响因子：
4.2
作者：
Duffy, Jeanne F.;Zeitzer, Jamie M.;Czeisler, Charles A.
通讯作者：
Czeisler, Charles A.
影响因子：
2.8
作者：
Lewy, AJ;Bauer, VK;Sack, RL
通讯作者：
Sack, RL