Does physical activity moderate the association between shorter leukocyte telomere length and incident coronary heart disease? Data from 54,180 UK Biobank participants.
Does physical activity moderate the association between shorter leukocyte telomere length and incident coronary heart disease? Data from 54,180 UK Biobank participants.
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DOI：
10.1007/s11357-023-00890-7
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发表时间：
2024-02
期刊：
影响因子：
5.6
通讯作者：
Kuo, Chia-Ling
中科院分区：
文献类型：
--
作者：
Xiang, Meiruo;Pilling, Luke C.;Melzer, David;Kirk, Ben;Duque, Gustavo;Liu, Rui;Kuchel, George A.;Wood, Andrew R.;Metcalf, Brad;Diniz, Breno S.;Hillsdon, Melvyn;Kuo, Chia-Ling
关键词：
端粒缩短是一种生物衰老的标志。端粒长度短的影响可能是通过增加体力活动来降低多种衰老相关疾病的风险，包括冠心病（CHD）。目的是评估基于加速度计的体力活动（阿帕）对人群样本中相对较短的白细胞端粒长度（LTL）与冠心病事件之间的关联的调节作用。数据来自英国生物银行参与者，具有至少6.5天的良好校准的加速度计数据（n = 54，180）。使用多重定量聚合酶链反应（qPCR）技术，通过比较端粒扩增产物（T）与单拷贝基因（S）的量，以T/S比测量基线时（阿帕评估前5-6年）的相对平均LTL。阿帕测量包括事件总数（至少10秒持续体力活动> 32毫重力[mg]）、总体积、平均持续时间、平均强度和所有事件的峰值强度。使用校正协变量的考克斯比例风险模型，LTL、阿帕指标及其相互作用与CHD事件相关（平均随访6.8年）。LTL较长（相对于样本分布）与CHD发生率降低相关（LTL每增加一个标准差[SD]，调整后的风险比[aHR] = 0.94，[95% CI，0.90 - 0.99]，P = 0.010）。阿帕总量增加可降低CHD发病率（aHR = 0.82/LTL增加SD，[95% CI，0.71 - 0.95]，P = 0.010），但随着事件总数增加而增加在控制其他阿帕指标和协变量后，（LTL每SD增加aHR = 1.11，[95% CI，1.02 - 1.21]，P = 0.020）。然而，LTL和阿帕指标之间的相互作用无统计学意义（P = .171）。在线版本包含补充材料，可通过10.1007/s11357-023-00890-7获得。
Telomere shortening is a biological aging hallmark. The effect of short telomere length may be targeted by increased physical activity to reduce the risk of multiple aging-related diseases, including coronary heart disease (CHD). The objective was to assess the moderation effect of accelerometer-based physical activity (aPA) on the association between shorter leukocyte telomere length (LTL) relatively in the population sample and incident CHD. Data were from the UK Biobank participants with well-calibrated accelerometer data for at least 6.5 days (n = 54,180). Relative mean LTL at baseline (5–6 years prior to aPA assessment) was measured in T/S ratio, using a multiplex quantitative polymerase chain reaction (qPCR) technology, by comparing the amount of the telomere amplification product (T) to that of a single-copy gene (S). aPA measures included total number of events (at least 10-s continued physical activity > 32 milligravities [mg]), total volume, mean duration, mean intensity, and peak intensity of all events. LTL, aPA measures, and their interactions were associated with incident CHD (mean follow-up 6.8 years) using Cox proportional hazards models adjusting for covariates. Longer LTL (relative to the sample distribution) was associated with reduced incidence of CHD (adjusted hazard ratio [aHR] = 0.94 per standard deviation [SD] increase in LTL, [95% CI, 0.90 to 0.99], P = .010). Incidence of CHD was reduced by higher total volume of aPA (aHR = 0.82 per SD increase in LTL, [95% CI, 0.71 to 0.95], P = .010) but increased by higher total number of events (aHR = 1.11 per SD increase in LTL, [95% CI, 1.02 to 1.21], P = .020) after controlling for other aPA measures and covariates. However, none of the interactions between LTL and aPA measures was statistically significant (P = .171). The online version contains supplementary material available at 10.1007/s11357-023-00890-7.
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影响因子：
64.5
作者：
López-Otín C;Blasco MA;Partridge L;Serrano M;Kroemer G
通讯作者：
Kroemer G
在健康、衰老和身体成分研究中，累积炎症负荷与白细胞端粒长度短有关。
影响因子：
3.7
作者：
O'Donovan A;Pantell MS;Puterman E;Dhabhar FS;Blackburn EH;Yaffe K;Cawthon RM;Opresko PL;Hsueh WC;Satterfield S;Newman AB;Ayonayon HN;Rubin SM;Harris TB;Epel ES;Health Aging and Body Composition Study
通讯作者：
Health Aging and Body Composition Study
影响因子：
64.8
作者：
Bycroft C;Freeman C;Petkova D;Band G;Elliott LT;Sharp K;Motyer A;Vukcevic D;Delaneau O;O'Connell J;Cortes A;Welsh S;Young A;Effingham M;McVean G;Leslie S;Allen N;Donnelly P;Marchini J
通讯作者：
Marchini J
影响因子：
5
作者：
Fry A;Littlejohns TJ;Sudlow C;Doherty N;Adamska L;Sprosen T;Collins R;Allen NE
通讯作者：
Allen NE
影响因子：
3.7
作者：
HAYFLICK, L;MOORHEAD, PS
通讯作者：
MOORHEAD, PS