Nanotechnology-based electrochemical sensors for biomonitoring chemical exposures.
Nanotechnology-based electrochemical sensors for biomonitoring chemical exposures.
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DOI：
10.1038/jes.2008.71
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发表时间：
2009-01
影响因子：
4.5
通讯作者：
中科院分区：
文献类型：
--
作者：
剂量测量和建模的结合代表了破译化学品暴露与疾病结果之间关系的一种有前途的策略。为了支持生物监测计划的制定和实施，需要测量外源性物质暴露的定量技术。基于便携式纳米技术的电化学传感器的开发有可能满足对一系列化学标记物进行生物监测的低成本、快速、高通量和超灵敏探测器的需求。讨论了具有 pM 灵敏度、高通量和低样品需求 (<50uL) 的高选择性电化学 (EC) 传感器。这些便携式分析系统与现有技术相比具有许多优势，因此有可能代表下一代生物监测分析仪。本手稿重点介绍了基于 EC 检测的现场可部署分析仪器开发的研究。提供了 EC 检测方法以及纳米材料在这些传感器开发中的综合使用的背景信息和总体概述。介绍了使用各种类型的丝网印刷电极、集成纳米材料和免疫分析的 EC 传感器的新发展。 EC 传感器最近在评估农药暴露或检测疾病生物标志物方面的应用突出显示了监测化学代谢物、酶活性或疾病蛋白质生物标志物的能力。此外，还讨论了推进使用 EC 平台进行剂量测定研究的未来考虑因素和机会。
The coupling of dosimetry measurements and modeling represents a promising strategy for deciphering the relationship between chemical exposure and disease outcome. To support the development and implementation of biological monitoring programs, quantitative technologies for measuring xenobiotic exposure are needed. The development of portable nanotechnology-based electrochemical sensors has the potential to meet the needs for low cost, rapid, high-throughput and ultrasensitive detectors for biomonitoring an array of chemical markers. Highly selective electrochemical (EC) sensors capable of pM sensitivity, high-throughput and low sample requirements (<50uL) are discussed. These portable analytical systems have many advantages over currently available technologies, thus potentially representing the next-generation of biomonitoring analyzers. This manuscript highlights research focused on the development of field-deployable analytical instruments based on EC detection. Background information and a general overview of EC detection methods and integrated use of nanomaterials in the development of these sensors are provided. New developments in EC sensors using various types of screen-printed electrodes, integrated nanomaterials, and immunoassays are presented. Recent applications of EC sensors for assessing exposure to pesticides or detecting biomarkers of disease are highlighted to demonstrate the ability to monitor chemical metabolites, enzyme activity, or protein biomarkers of disease. In addition, future considerations and opportunities for advancing the use of EC platforms for dosimetric studies are discussed.
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影响因子：
7.4
作者：
Authier, L;Grossiord, C;Limoges, B
通讯作者：
Limoges, B
影响因子：
6.2
作者：
Collins, GE;Lu, Q
通讯作者：
Lu, Q
影响因子：
6.1
作者：
Black, RM;Harrison, JM;Read, RW
通讯作者：
Read, RW
影响因子：
10.4
作者：
Bradman A;Eskenazi B;Barr DB;Bravo R;Castorina R;Chevrier J;Kogut K;Harnly ME;McKone TE
通讯作者：
McKone TE
影响因子：
7.4
作者：
Castellana, ET;Kataoka, S;Cremer, PS
通讯作者：
Cremer, PS