Defining the Scope of Exposome Studies and Research Needs from a Multidisciplinary Perspective.
Defining the Scope of Exposome Studies and Research Needs from a Multidisciplinary Perspective.
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DOI：
10.1021/acs.estlett.1c00648
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发表时间：
2021-10-12
影响因子：
10.9
通讯作者：
Wheelock CE
中科院分区：
文献类型：
--
作者：
Zhang P;Carlsten C;Chaleckis R;Hanhineva K;Huang M;Isobe T;Koistinen VM;Meister I;Papazian S;Sdougkou K;Xie H;Martin JW;Rappaport SM;Tsugawa H;Walker DI;Woodruff TJ;Wright RO;Wheelock CE
15年前提出了环境问题的概念，以反映环境对健康和疾病的重要作用。虽然最初被视为一种战斗召唤，以制定适用于个人和整个生命过程的更全面的接触评估方法，但问题组的范围现已扩大到包括相关的生物反应。为了探讨这些概念，群马大学高级研究计划（GIAR，日本）主办了一个研讨会，从国际和多学科的角度讨论电子经济学的范围。该全球视角是讨论的总结，重点是（1）暴露组学的自上而下、自下而上和功能性方法，（2）基于LC和GC的高分辨率质谱方法的集成和标准化的必要性，用于非目标暴露组分析，（3）暴露组学研究的设计，（4）开放科学工作流程的要求，包括质谱库和公共数据库，（5）需要对质谱基础设施进行大量投资，以便对干扰素组进行测序，以及（6）干扰素组在精确医学和营养中的作用，以创建个性化的环境暴露概况。就关键问题提出了建议，以鼓励在电子经济学方面继续取得进展和开展合作。
The concept of the exposome was introduced over 15 years ago to reflect the important role that the environment exerts on health and disease. While originally viewed as a call-to-arms to develop more comprehensive exposure assessment methods applicable at the individual level and throughout the life course, the scope of the exposome has now expanded to include the associated biological response. In order to explore these concepts, a workshop was hosted by the Gunma University Initiative for Advanced Research (GIAR, Japan) to discuss the scope of exposomics from an international and multidisciplinary perspective. This Global Perspective is a summary of the discussions with emphasis on (1) top-down, bottom-up, and functional approaches to exposomics, (2) the need for integration and standardization of LC- and GC-based high-resolution mass spectrometry methods for untargeted exposome analyses, (3) the design of an exposomics study, (4) the requirement for open science workflows including mass spectral libraries and public databases, (5) the necessity for large investments in mass spectrometry infrastructure in order to sequence the exposome, and (6) the role of the exposome in precision medicine and nutrition to create personalized environmental exposure profiles. Recommendations are made on key issues to encourage continued advancement and cooperation in exposomics.
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影响因子：
11.8
作者：
Andra SS;Austin C;Patel D;Dolios G;Awawda M;Arora M
通讯作者：
Arora M
DOI：
10.1007/s13167-021-00241-6
发表时间：
2021-06
期刊：
The EPMA journal
影响因子：
--
作者：
Brunmair J;Bileck A;Stimpfl T;Raible F;Del Favero G;Meier-Menches SM;Gerner C
通讯作者：
Gerner C
影响因子：
5
作者：
DeBord DG;Carreón T;Lentz TJ;Middendorf PJ;Hoover MD;Schulte PA
通讯作者：
Schulte PA
影响因子：
10.4
作者：
Dennis KK;Auerbach SS;Balshaw DM;Cui Y;Fallin MD;Smith MT;Spira A;Sumner S;Miller GW
通讯作者：
Miller GW
影响因子：
5.2
作者：
Avila-Tang E;Al-Delaimy WK;Ashley DL;Benowitz N;Bernert JT;Kim S;Samet JM;Hecht SS
通讯作者：
Hecht SS