Environmental and occupational pesticide exposure and human sperm parameters: a systematic review.
Environmental and occupational pesticide exposure and human sperm parameters: a systematic review.
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DOI：
10.1016/j.tox.2013.02.005
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发表时间：
2013-05-10
期刊：
影响因子：
4.5
通讯作者：
Perry MJ
中科院分区：
文献类型：
--
作者：
Martenies SE;Perry MJ
持续关注的是环境或职业暴露于农药和精液质量参数之间的关系。先前的研究表明，接触各种类型的杀虫剂与精子健康下降之间可能存在关联。本综述的目的是总结最新的证据有关农药暴露和常用的精液质量参数，包括浓度，活力和形态。最近的文献检索了2007年1月至2012年8月期间发表的关于环境或职业农药暴露的研究。该综述包括17项研究，其中15项报告了农药暴露与精液质量指标之间的显著关联。两项研究还调查了遗传多态性在这些关联的强度或方向中可能发挥的作用。研究的具体农药包括二氯二苯三氯乙烷（DDT）、六氯环己烷（HCH）和阿维菌素。拟除虫菊酯类杀虫剂和有机磷酸酯被作为杀虫剂类别进行分析，而不是作为单独的化合物进行分析，这主要是由于接触评估技术的局限性。总的来说，大多数研究报告了农药暴露与精子参数之间的显著关联。在所有被调查的农药类别中，精子浓度的降低是最常见的报告发现。运动能力下降也与接触每一类农药有关，尽管这些发现在研究中不太常见。农药暴露和精子形态之间的联系不太清楚，只有两项研究报告了这种联系。本综述中提出的证据继续支持这样一种假设，即接触与环境或职业相关水平的农药可能与精子健康下降有关。该领域未来的工作应侧重于特定农药或代谢产物与精子质量参数之间的关系。分析不同遗传特征的影响，特别是与农药代谢有关的基因，也需要进一步关注。
Of continuing concern are the associations between environmental or occupational exposures to pesticides and semen quality parameters. Prior research has indicated that there may be associations between exposure to pesticides of a variety of classes and decreased sperm health. The intent of this review was to summarize the most recent evidence related to pesticide exposures and commonly used semen quality parameters, including concentration, motility and morphology. The recent literature was searched for studies published between January, 2007 and August, 2012 that focused on environmental or occupational pesticide exposures. Included in the review are 17 studies, 15 of which reported significant associations between exposure to pesticides and semen quality indicators. Two studies also investigated the roles genetic polymorphisms may play in the strength or directions of these associations. Specific pesticides targeted for study included dichlorodiphenyltrichloroethane (DDT), hexachlorocyclohexane (HCH), and abamectin. Pyrethroids and organophosphates were analyzed as classes of pesticides rather than as individual compounds, primarily due to the limitations of exposure assessment techniques. Overall, a majority of the studies reported significant associations between pesticide exposure and sperm parameters. A decrease in sperm concentration was the most commonly reported finding among all of the pesticide classes investigated. Decreased motility was also associated with exposures to each of the pesticide classes, although these findings were less frequent across studies. An association between pesticide exposure and sperm morphology was less clear, with only two studies reporting an association. The evidence presented in this review continues to support the hypothesis that exposures to pesticides at environmentally or occupationally relevant levels may be associated with decreased sperm health. Future work in this area should focus on associations between specific pesticides or metabolic products and sperm quality parameters. Analysis of effects of varying genetic characteristics, especially in genes related to pesticide metabolism, also needs further attention.
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影响因子：
6.1
作者：
Eskenazi, B;Wyrobek, AJ;Moore, D
通讯作者：
Moore, D
影响因子：
6.1
作者：
Blanco-Munoz, Julia;Mayanin Morales, Magally;Cebrian, Mariano E.
通讯作者：
Cebrian, Mariano E.
影响因子：
2.9
作者：
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通讯作者：
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影响因子：
3.3
作者：
Gallegos-Avila, Guadalupe;Ancer-Rodriguez, Jesus;Jaramillo-Rangel, Gilberto
通讯作者：
Jaramillo-Rangel, Gilberto
影响因子：
13.3
作者：
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通讯作者：
Vogelsong, Kirsten M.