Voluntary physical exercise protects against behavioral and endocrine reactivity to social and environmental stressors in the prairie vole.
Voluntary physical exercise protects against behavioral and endocrine reactivity to social and environmental stressors in the prairie vole.
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DOI：
10.1080/17470919.2017.1365761
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发表时间：
2018-10
影响因子：
2
通讯作者：
Grippo AJ
中科院分区：
文献类型：
--
作者：
Watanasriyakul WT;Wardwell J;McNeal N;Schultz R;Woodbury M;Dagner A;Cox M;Grippo AJ
体育活动已被证明可以对抗压力的有害影响。本研究在草原田鼠模型中考察了运动对社会隔离和慢性轻度应激（CMS）的潜在保护作用。将雌性田鼠隔离4周，在最后2周期间添加CMS。在最后的两周里，一半的田鼠被允许使用跑步轮，而另一半则保持久坐不动。动物接受行为测试以评估抑郁和焦虑行为。在一个动物亚组中，在行为测试后10分钟收集血浆用于皮质酮分析。在一个单独的动物亚组中，在行为测试后2小时收集大脑用于室旁核（PVN）中的cFos分析。与久坐组的动物相比，运动组的田鼠表现出明显较低的抑郁和焦虑样行为，并且皮质酮水平也明显较低。各组间PVN cFos活性无差异。有趣的是，与低活动亚组和高活动亚组的动物相比，适度运动的动物表现出较低水平的抑郁样行为，并且皮质酮反应性减弱。目前的研究结果表明，体育活动可以防止社会和环境压力的组合。
Physical activity has been shown to combat detrimental effects of stress. The current study examined the potential protective effects of exercise against a combination of social isolation and chronic mild stress (CMS) in a prairie vole model. Female voles were isolated for 4 weeks, with the addition of CMS during the final 2 weeks. Half of the voles were allowed access to a running wheel during this final 2 weeks, while the other half remained sedentary. Animals underwent behavioral tests to assess depressive- and anxiety-behaviors. In a subset of animals, plasma was collected 10 minutes after behavioral testing for corticosterone analysis. In a separate subset of animals, brains were collected 2 hours after behavioral testing for cFos analysis in the paraventricular nucleus (PVN). Voles in the exercise group displayed significantly lower depressive- and anxiety-like behaviors, and also had significantly lower corticosterone levels, compared to animals in the sedentary group. There was no difference in PVN cFos activity between groups. Interestingly, animals that moderately exercised displayed lower levels of depressive-like behavior and attenuated corticosterone reactivity compared to animals in the low and high activity subgroups. Current findings suggest that physical activity can protect against a combination of social and environmental stressors.
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影响因子：
3.3
作者：
Grippo AJ;Ihm E;Wardwell J;McNeal N;Scotti MA;Moenk DA;Chandler DL;LaRocca MA;Preihs K
通讯作者：
Preihs K
DOI：
10.1073/pnas.1015950108
发表时间：
2011-02-15
影响因子：
11.1
作者：
Erickson, Kirk I.;Voss, Michelle W.;Kramer, Arthur F.
通讯作者：
Kramer, Arthur F.
影响因子：
2.9
作者：
Grippo, AJ;Francis, J;Johnson, AK
通讯作者：
Johnson, AK
影响因子：
3.7
作者：
Grippo, Angela J.;Gerena, Davida;Carter, C. Sue
通讯作者：
Carter, C. Sue
影响因子：
3.2
作者：
Campeau S;Nyhuis TJ;Sasse SK;Kryskow EM;Herlihy L;Masini CV;Babb JA;Greenwood BN;Fleshner M;Day HE
通讯作者：
Day HE