The serotonin transporter promoter polymorphism is associated with cortisol response to psychosocial stress.
The serotonin transporter promoter polymorphism is associated with cortisol response to psychosocial stress.
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DOI：
10.1016/j.biopsych.2009.10.021
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发表时间：
2010-03-01
影响因子：
10.6
通讯作者：
Taylor, Shelley E.
中科院分区：
文献类型：
--
作者：
Way, Baldwin M.;Taylor, Shelley E.
在多个心理健康相关的措施，多态性（5-HTTLPR）内的5-羟色胺转运蛋白基因的启动子已与不同的心理敏感性，压力的经验。然而，这种多态性导致心理功能障碍风险的具体机制尚不清楚。因此，我们研究了皮质醇反应性的心理社会压力作为一个潜在的中间表型，可能易患这种风险。对182名心理健康的年轻人进行了5-HTTLPR基因分型。每个参与者发表演讲，并在三种观众条件之一中进行心算：一个批评性的评价观众，一个支持性的评价观众，或者没有观众。唾液皮质醇在基线和应激源发作后20，40和75分钟进行采样。这两个评价观众条件引起了类似的，显着增加皮质醇显着大于在没有观众控制。评价观众的条件下，皮质醇反应性和5-HTTLPR之间的显着关系，与短/短的基因型表现出最大的反应。内部分析显示，5-HTTLPR显着相关的皮质醇反应，只有在消极的观众条件，这表明，短/短的个人可能特别容易受到社会威胁。5-HTTLPR的短/短基因型与对社会威胁的更大皮质醇反应性相关。当矮个子/矮个子个体经历压力性生活事件时，他们可能面临更大的风险，出现与皮质醇暴露增加相关的不良心理和身体健康后果。
Across multiple mental health-related measures, a polymorphism (5-HTTLPR) within the promoter of the serotonin transporter gene has been associated with differential psychological sensitivity to stressful experiences. Yet, the specific mechanisms by which this polymorphism contributes to risk for psychological dysfunction is unclear. Therefore, we investigated cortisol reactivity to psychosocial stress as a potential intermediate phenotype that may predispose to such risk. A psychologically healthy sample of 182 young adults were genotyped for the 5-HTTLPR. Each participant delivered a speech and performed mental arithmetic in one of three audience conditions: A critical evaluative audience, a supportive evaluative audience, or no audience. Salivary cortisol was sampled at baseline and at 20, 40, and 75 minutes after stressor onset. The two evaluative audience conditions elicited similar, significant increases in cortisol that were significantly greater than in the no audience control. The evaluative audience conditions revealed a significant relationship between cortisol reactivity and the 5-HTTLPR, with the short/short genotype showing the greatest reactivity. Internal analyses revealed that the 5-HTTLPR was significantly associated with cortisol reactivity in the negative audience condition only, suggesting that short/short individuals may be especially vulnerable to social threat. The short/short genotype of the 5-HTTLPR is associated with greater cortisol reactivity to social threat. When short/short individuals experience stressful life events, they may be at greater risk for the adverse psychological and physical health consequences associated with heightened cortisol exposure.
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影响因子：
10.6
作者：
Covault, Jonathan;Tennen, Howard;Kranzler, Henry R.
通讯作者：
Kranzler, Henry R.
影响因子：
2.5
作者：
Furmark, T;Tillfors, M;Fredrikson, M
通讯作者：
Fredrikson, M
影响因子：
3.2
作者：
KIRSCHBAUM, C;PIRKE, KM;HELLHAMMER, DH
通讯作者：
HELLHAMMER, DH
影响因子：
22.4
作者：
Hutchison, KE;Stallings, M;Bryan, A
通讯作者：
Bryan, A
影响因子：
8.2
作者：
Monroe, Scott M.;Reid, Mark W.
通讯作者：
Reid, Mark W.