Different indices of fetal growth predict bone size and volumetric density at 4 years of age.
Different indices of fetal growth predict bone size and volumetric density at 4 years of age.
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DOI：
10.1359/jbmr.091022
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发表时间：
2010-04
期刊：
影响因子：
--
通讯作者：
SWS Study Group
中科院分区：
文献类型：
--
作者：
Harvey NC;Mahon PA;Robinson SM;Nisbet CE;Javaid MK;Crozier SR;Inskip HM;Godfrey KM;Arden NK;Dennison EM;Cooper C;SWS Study Group
我们以前已经证明，较高的出生体重与更大的峰值和以后的生活骨矿物质含量和母亲的身体构造，饮食和生活方式影响产前骨矿物质的积累。为了进一步研究产前对骨骼健康的影响，我们将胎儿生长的超声测量与儿童骨骼的大小和密度联系起来。我们从南安普顿妇女调查的参与者的超声测量中得出胎儿股骨长度和腹围以及孕19 - 34周的条件生长速度的Z分数。共有380名后代在4岁时接受双能X线吸收测定法（DXA）[全身减去头骨面积（BA），骨矿物质含量（BMC），面积骨矿物质密度（aBMD）和估计的体积BMD（vBMD）]。体积骨矿物质密度估计使用BMC调整BA，身高和体重。19 ~ 34周胎儿股骨生长速度加快与儿童期骨骼尺寸增大密切相关（BA：r = 0.30，p < .0001），但与体积密度无关（vBMD：r = 0.03，p = .51）。相反，19- 34周胎儿腹部生长速度越快，儿童期体积密度越大（vBMD：r = 0.15，p = 0.004），但与骨骼大小无关（BA：r = 0.06，p = 0.21）。两种胎儿测量值均与BMC和aBMD呈正相关，这两种指标受尺寸和密度的影响。胎儿股骨长度在妊娠19 ~ 34周的增长速度可以预测4岁时的骨骼大小，而腹部的增长速度（肝脏体积和肥胖的测量）可以预测体积密度。这些结果表明对骨骼大小和体积密度的影响之间的不一致。
We have demonstrated previously that higher birth weight is associated with greater peak and later-life bone mineral content and that maternal body build, diet, and lifestyle influence prenatal bone mineral accrual. To examine prenatal influences on bone health further, we related ultrasound measures of fetal growth to childhood bone size and density. We derived Z-scores for fetal femur length and abdominal circumference and conditional growth velocity from 19 to 34 weeks’ gestation from ultrasound measurements in participants in the Southampton Women’s Survey. A total of 380 of the offspring underwent dual-energy X-ray absorptiometry (DXA) at age 4 years [whole body minus head bone area (BA), bone mineral content (BMC), areal bone mineral density (aBMD), and estimated volumetric BMD (vBMD)]. Volumetric bone mineral density was estimated using BMC adjusted for BA, height, and weight. A higher velocity of 19- to 34-week fetal femur growth was strongly associated with greater childhood skeletal size (BA: r = 0.30, p < .0001) but not with volumetric density (vBMD: r = 0.03, p = .51). Conversely, a higher velocity of 19- to 34-week fetal abdominal growth was associated with greater childhood volumetric density (vBMD: r = 0.15, p = .004) but not with skeletal size (BA: r = 0.06, p = .21). Both fetal measurements were positively associated with BMC and aBMD, indices influenced by both size and density. The velocity of fetal femur length growth from 19 to 34 weeks’ gestation predicted childhood skeletal size at age 4 years, whereas the velocity of abdominal growth (a measure of liver volume and adiposity) predicted volumetric density. These results suggest a discordance between influences on skeletal size and volumetric density.
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影响因子：
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