An angiographic technique for coronary fractional flow reserve measurement: in vivo validation.
An angiographic technique for coronary fractional flow reserve measurement: in vivo validation.
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DOI：
10.1007/s10554-012-0119-0
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发表时间：
2013-03
期刊：
影响因子：
--
通讯作者：
Molloi S
中科院分区：
文献类型：
--
作者：
Takarada S;Zhang Z;Molloi S
血流储备分数 (FFR) 是临床环境中重要的预后决定因素。然而，其测量目前需要使用有创压力线，而基于首过分布分析和缩放定律的血管造影技术可仅使用图像数据来测量FFR。八只麻醉猪的左前降支 (LAD) 冠状动脉近端装有流量探针。连续记录来自流量探头的体积血流量（Qp）、冠状动脉压力（Pa）和右心房压力（Pv）。基于流量探头的 FFR (FFRq) 是根据有狭窄和无狭窄的流量比率来测量的。为了确定基于血管造影的 FFR (FFRa)，计算了狭窄存在下的血流量 (QS) 与理论上正常血流量 (QN) 的比率。使用血管造影图像绘制 LAD 动脉床中的感兴趣区域以生成时间-密度曲线。 QS 使用时间-密度曲线进行测量，并假设血液在注射过程中被造影剂暂时替换。 QN 是根据比例定律根据总冠状动脉体积估算的。在研究过程中连续获得 FFR (FFRp) 的压力线测量值，FFRp 是根据远端冠状动脉压力 (Pd) 除以近端压力 (Pa) 的比值计算得出的。总共进行了 54 次 FFRa、FFRp 和 FFRq 测量。 FFRa 与 FFRq 表现出良好的相关性（FFRa =0.97 FFRq +0.06，r2=0.80，p<0.001），尽管 FFRp 高估了 FFRq（FFRp=0.657 FFRq+0.313，r2 =0.710，p<0.0001）。此外，Bland-Altman 分析显示 FFRa 和 FFRq 之间非常一致。这种测量 FFR 的血管造影技术可用于在不需要压力线的常规诊断心导管插入术期间评估冠状动脉狭窄的解剖学和生理学评估。
Fractional flow reserve (FFR) is an important prognostic determinant in a clinical setting. However, its measurement currently requires the use of invasive pressure wire, while an angiographic technique based on first-pass distribution analysis and scaling laws can be used to measure FFR using only image data. Eight anesthetized swine were instrumented with flow probe on the proximal segment of the left anterior descending (LAD) coronary arteries. Volumetric blood flow from the flow probe (Qp), coronary pressure (Pa) and right atrium pressure (Pv) were continuously recorded. Flow probe-based FFR (FFRq) was measured from the ratio of flow with and without stenosis. To determine the angiography-based FFR (FFRa), the ratio of blood flow in the presence of a stenosis (QS) to theoretically normal blood flow (QN) was calculated. A region of interest in the LAD arterial bed was drawn to generate time-density curves using angiographic images. QS was measured using a time-density curve and the assumption that blood was momentarily replaced with contrast agent during the injection. QN was estimated from the total coronary arterial volume using scaling laws. Pressure-wire measurements of FFR (FFRp), which was calculated from the ratio of distal coronary pressure (Pd) divided by proximal pressure (Pa), were continuously obtained during the study. A total of 54 measurements of FFRa, FFRp, and FFRq were taken. FFRa showed a good correlation with FFRq (FFRa =0.97 FFRq +0.06, r2=0.80, p<0.001), although FFRp overestimated the FFRq (FFRp=0.657 FFRq+0.313, r2 =0.710, p<0.0001). Additionally, the Bland-Altman analysis showed a close agreement between FFRa and FFRq. This angiographic technique to measure FFR can potentially be used to evaluate both anatomical and physiological assessments of a coronary stenosis during routine diagnostic cardiac catheterization that requires no pressure wires.
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影响因子：
2.1
作者：
Molloi, Sabee;Chalyan, David;Le, Huy;Wong, Jerry T.
通讯作者：
Wong, Jerry T.
影响因子：
37.8
作者：
Molloi, S;Ersahin, A;Leung, CY
通讯作者：
Leung, CY
影响因子：
37.8
作者：
PANTELY, GA;LADLEY, HD;BRISTOW, JD
通讯作者：
BRISTOW, JD
影响因子：
37.8
作者：
Molloi, S;Kassab, GS;Zhou, YF
通讯作者：
Zhou, YF
影响因子：
3.3
作者：
Choy, Jenny Susana;Kassab, Ghassan S.
通讯作者：
Kassab, Ghassan S.