Impact of symptoms by gender and age in Japanese subjects with irritable bowel syndrome with constipation (IBS-C): a large population-based internet survey.
Impact of symptoms by gender and age in Japanese subjects with irritable bowel syndrome with constipation (IBS-C): a large population-based internet survey.
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DOI：
10.1186/s13030-018-0131-2
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发表时间：
2018
影响因子：
2.1
通讯作者：
Fukudo S
中科院分区：
文献类型：
--
作者：
Kosako M;Akiho H;Miwa H;Kanazawa M;Fukudo S
肠易激综合征伴便秘(IBS-C)是一种典型的心身疾病。一些病理生理因素与IBS症状有关，如胃肠动力调节、内脏高敏感性、肠脑轴失调、遗传和环境因素、感染后遗症和心理社会障碍。IBS-C的生物、心理和社会方面很可能是其性别和年龄影响的基础。然而，性别和年龄对IBS-C各症状的影响还不是很清楚。我们假设，在女性和20-49岁的受试者中，每种IBS-C症状的表达率都高于男性和50-79岁的受试者。我们对日本普通民众中的3万名成年人进行了互联网调查。IBS-C受试者被要求回答一份关于焦虑程度、对排便习惯的想法、他们的主要胃肠道症状以及恶化因素的问卷。分析性别、年龄与IBS-C症状的相关性。按性别分析，女性患者腹部不适、腹胀和腹胀的发生率显著高于男性(66.5%vs.58.7%，p <； 0.05；54.7%vs.43.6%，p <； 0.01；18.9%vs.9.6%，p <； 0.01)。按年龄分析，20~49岁组腹胀和腹痛的发生率显著高于50~79岁组(55.7%vs.46.8%，p <； 0.001；36.6%vs.20.6%，p <； 0.05)。相比之下，在IBS-C受试者中，最常见和最令人烦恼的症状(腹胀)没有性别或年龄差异。部分IBS-C症状在女性和20~49岁人群中的表达率分别高于男性和50~79岁人群。重要的是要了解性别和年龄对症状的影响，从生物心理社会的角度评估IBS-C的病理。虽然这项调查是一项匿名的互联网调查，但作为在线回应，我们获得了研究的知情同意。这项研究的披露得到了东北大学研究生院伦理委员会的批准(批准编号：2015-1-405)。
Irritable bowel syndrome with constipation (IBS-C) is a representative psychosomatic disorder. Several pathophysiological factors have been linked to IBS symptoms such as the modulation of gastrointestinal motility, visceral hypersensitivity, dysregulation of the gut-brain axis, genetic and environmental factors, sequelae of infection, and psychosocial disorders. It is likely that biopsychosocial aspects of IBS-C underlie its gender and age effects. However, the influence of each symptom of IBS-C by gender and age is not well understood. We hypothesized that the expression rate of each IBS-C symptom in females and in subjects aged 20–49 years was higher than that of subjects who were male and aged 50–79 years. We conducted an internet survey of 30,000 adults from the general Japanese population. IBS-C subjects were asked to answer a questionnaire on the degree of anxiety, thoughts about bowel habits, and their dominant gastrointestinal symptoms together with exacerbation factors. The correlation between gender and age and IBS-C symptoms was analyzed. When analyzed by gender, the expression rate of abdominal discomfort, abdominal distention, and abdominal fullness was significantly higher in female than male IBS-C subjects (66.5% vs. 58.7%, p < 0.05; 54.7% vs. 43.6%, p < 0.01; 18.9% vs. 9.6%, p < 0.01, respectively). When analyzed by age, the expression rate of abdominal distention and abdominal pain was significantly higher among IBS-C subjects aged 20–49 years than those aged 50–79 years (55.7% vs. 46.8%, p < 0.05; 36.6% vs. 20.6%, p < 0.001, respectively). In contrast, there was no gender or age differences with regard to the most common and bothersome symptom (abdominal bloating) among IBS-C subjects. The expression rate of some IBS-C symptoms was higher among females and those aged 20–49 years than males and those aged 50–79 years, respectively. It is important to understand the impact of symptoms by gender and age to evaluate the pathology of IBS-C from a biopsychosocial perspective. Although this survey was an anonymous internet survey, we obtained informed consent for the study as an online response. The disclosure of this study was approved by the Ethics Committee of Tohoku University Graduate School of Medicine (approval number: 2015–1-405).
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影响因子：
3.5
作者：
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通讯作者：
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Naliboff, B
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