Repeatability of the macular pigment spatial profile: A comparison of objective versus subjective classification.
Repeatability of the macular pigment spatial profile: A comparison of objective versus subjective classification.
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DOI：
10.1111/aos.13725
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发表时间：
2018-11
影响因子：
3.4
通讯作者：
Huntjens B
中科院分区：
文献类型：
--
作者：
Ctori I;Mahroo OA;Williams KM;Hammond CJ;Huntjens B
黄斑色素（MP）空间轮廓表型的分类各不相同，通常基于主观视觉。我们研究了MP光密度（MPOD）的可重复性，比较了客观和主观分析系统。对40名健康个体（39±9岁）单次访视中两次扫描的双波长眼底自体荧光（FAF）获得的点MPOD值（0-3.8°）计算重复性系数（CoR）。对于每个个体的数据集，使用客观方法（基于偏离指数拟合的偏差）以及主观视觉分析，将MP配置文件分类为指数型，环状型或中心倾角。对88对同卵双胞胎（MZ）和69对异卵双胞胎（DZ）的FAF图像进行了客观谱分析，并确定了环状谱的一致性和遗传力。在0°时，CoR为0.23，在0.8°时为0.06。扫描之间的客观轮廓一致性非常好（κ = 0.85, 95% CI 0.69至1.00;p < 0.0005）。主观分析显示扫描之间的一致性中等（κ = 0.48, 95% CI 0.23至0.73;p < 0.0005）。客观分类与主观分类的一致性较低（κ = 0.23, 95% CI 0.04 ~ 0.42; p = 0.02）。使用客观分析，MZ双胞胎的环状轮廓一致性为0.74，而DZ双胞胎的一致性为0.36。遗传率为81.5%（95%置信区间为61.1 ~ 93.1%）。与目测评估相比，客观MP分析是一种更可靠的方法，应在未来的观察性和干预性研究中加以考虑。此外，MP谱表型具有较高的遗传力。
Classification of macular pigment (MP) spatial profile phenotypes varies and is often based on subjective visualisation. We investigated repeatability of MP optical density (MPOD) comparing an objective versus subjective profiling system. The coefficient of repeatability (CoR) was calculated for point MPOD values (0–3.8°) obtained by dual‐wavelength fundus autofluorescence (FAF) from two scans obtained in a single visit of 40 healthy individuals (39 ± 9 years). For each individual's dataset, the MP profile was classified as exponential, ring‐like or central dip using an objective method (based on deviations away from an exponential fit), as well as by subjective visual profiling. Existing FAF images of 88 monozygotic (MZ) and 69 dizygotic (DZ) twin pairs were reanalysed using the objective profiling method and concordance and heritability of ring‐like profiles determined. The CoR was 0.23 at 0° and 0.06 at 0.8°. Agreement of objective profiling between scans was excellent (κ = 0.85, 95% CI 0.69 to 1.00; p < 0.0005). Subjective profiling showed moderate agreement between scans (κ = 0.48, 95% CI 0.23 to 0.73; p < 0.0005). Agreement between objective and subjective classification was low (κ = 0.23, 95% CI 0.04 to 0.42; p = 0.02). Concordance for the ring‐like profile using objective profiling was 0.74 for MZ compared to 0.36 for DZ twins. Heritability was calculated as 81.5% (95% confidence interval 61.1–93.1%). Compared to visual assessment, objective MP profiling is a more reliable method and should be considered in future observational and interventional studies. In addition, MP profile phenotypes showed high heritability.
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影响因子：
4.4
作者：
Kirby, Mark L.;Galea, Martin;Nolan, John M.
通讯作者：
Nolan, John M.
DOI：
10.1364/josaa.18.001212
发表时间：
2001-06-01
影响因子：
1.9
作者：
Delori, FC;Goger, DG;Burns, SA
通讯作者：
Burns, SA
影响因子：
4.4
作者：
Dietzel, Martha;Zeimer, Meike;Hense, Hans-Werner
通讯作者：
Hense, Hans-Werner
影响因子：
5.2
作者：
Iannaccone, Alessandro;Carboni, Giovannella;Jennings, Barbara J.
通讯作者：
Jennings, Barbara J.
影响因子：
2.3
作者：
Putnam, Christopher M;Bassi, Carl J
通讯作者：
Bassi, Carl J