Evidence of infection with H4 and H11 avian influenza viruses among Lebanese chicken growers.
Evidence of infection with H4 and H11 avian influenza viruses among Lebanese chicken growers.
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DOI：
10.1371/journal.pone.0026818
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Webby RJ
中科院分区：
文献类型：
--
作者：
Kayali G;Barbour E;Dbaibo G;Tabet C;Saade M;Shaib HA;Debeauchamp J;Webby RJ
人类感染H5、H7和H9禽流感病毒的情况有很好的记录。接触家禽是人类感染这些病毒的最重要风险因素。关于人类感染其他低致病性禽流感病毒的数据很少，但表明可能会发生这种感染。黎巴嫩是一个地中海国家，位于两条主要的候鸟飞行路线下，是许多野生和家养鸟类的家园。该国以前的报告表明，低致病性禽流感病毒正在传播，但高致病性H5N1病毒尚未报告。为了研究黎巴嫩人感染禽流感病毒的程度，我们对200名家禽接触者和50名非接触者进行了血清阳性横断面研究。我们获得了他们的血清，并检测了是否存在针对H4至H16型禽流感病毒的抗体，并使用问卷收集了暴露数据。我们的微量中和试验结果表明，后院家禽养殖者可能以前感染过H4和H11禽流感病毒。我们用马红细胞血凝抑制试验证实了这些结果。我们的数据还显示，对每种病毒类型都有抗体的农民聚集在一个很小的地理区域，这表明未被识别的禽类疫情可能导致了这些人类感染。总之，这项研究表明，职业接触鸡肉是感染禽流感的危险因素，特别是在后院种植者中，H4和H11流感病毒可能具有跨越物种屏障感染人类的能力。
Human infections with H5, H7, and H9 avian influenza viruses are well documented. Exposure to poultry is the most important risk factor for humans becoming infected with these viruses. Data on human infection with other low pathogenicity avian influenza viruses is sparse but suggests that such infections may occur. Lebanon is a Mediterranean country lying under two major migratory birds flyways and is home to many wild and domestic bird species. Previous reports from this country demonstrated that low pathogenicity avian influenza viruses are in circulation but highly pathogenic H5N1 viruses were not reported. In order to study the extent of human infection with avian influenza viruses in Lebanon, we carried out a seroprevalence cross-sectional study into which 200 poultry-exposed individuals and 50 non-exposed controls were enrolled. We obtained their sera and tested it for the presence of antibodies against avian influenza viruses types H4 through H16 and used a questionnaire to collect exposure data. Our microneutralization assay results suggested that backyard poultry growers may have been previously infected with H4 and H11 avian influenza viruses. We confirmed these results by using a horse red blood cells hemagglutination inhibition assay. Our data also showed that farmers with antibodies against each virus type clustered in a small geographic area suggesting that unrecognized outbreaks among birds may have led to these human infections. In conclusion, this study suggests that occupational exposure to chicken is a risk factor for infection with avian influenza especially among backyard growers and that H4 and H11 influenza viruses may possess the ability to cross the species barrier to infect humans.
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