Apathy symptom profile and behavioral associations in frontotemporal dementia vs dementia of Alzheimer type.
Apathy symptom profile and behavioral associations in frontotemporal dementia vs dementia of Alzheimer type.
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DOI：
10.1001/archneurol.2009.92
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发表时间：
2009-07
影响因子：
--
通讯作者：
van Reekum R
中科院分区：
文献类型：
--
作者：
Chow TW;Binns MA;Cummings JL;Lam I;Black SE;Miller BL;Freedman M;Stuss DT;van Reekum R
冷漠是痴呆患者中非常常见和重要的问题，无论病因如何。额皮质下回路（FSC）综合征的观察表明，冷漠可能有情感，行为或认知的表现。我们探讨了是否冷漠表现在额颞叶痴呆症（FTD）与其主要前脑神经病理学与冷漠阿尔茨海默病（DAT）与其主要海马和颞顶神经病理学不同。我们还试图确定FSC综合征中报告的其他行为障碍是否与冷漠相关。调查.分析包括神经精神量表（NPI）子量表项目中的单个项目。冷漠/冷漠子量表的项目被一致指定为：A）情感=缺乏情感，B）行为=不活跃，放弃家务或C）认知=对他人的活动不感兴趣。相关的非冷漠NPI项目的比例进行了计算，并显示使用的冷漠域和痴呆诊断的比较，以方便？几个神经病学专业诊所贡献了我们的数据集的92名参与者与FTD和457 DAT。情感淡漠是更普遍的FTD比DAT，但当存在时，特定的情感淡漠症状在这两种痴呆症很少局限于三个领域之一的情感淡漠。伴有冷漠的烦躁是DAT组特有的，与FTD呈负相关。情感冷漠的参与者更频繁地在FTD（冲动和强迫）中同时出现眶额皮质下综合征。情感冷漠也与不合作的激动，愤怒，和身体激动在两种痴呆症。情感淡漠在FTD和DAT中很常见，但在FTD中更常见。当出现时，它通常涉及情感，行为和认知的变化。它与先前已被证明会影响患者安全，独立性和生活质量的行为有关。
Apathy is a very common and significant problem in patients with dementia, regardless of etiology. Observations on frontosubcortical circuit (FSC) syndromes indicate that apathy may have affective, behavioral or cognitive manifestations. We explored whether the apathy manifested in frontotemporal dementia (FTD) with its predominantly anterior brain neuropathology differs from the apathy in Alzheimer's disease (DAT) with its predominantly hippocampal and temporoparietal-based neuropathology. We also sought to determine whether other behavioral disturbances reported in FSC syndromes correlate with apathy. Survey. Analyses included individual items within Neuropsychiatric Inventory (NPI) subscale items. Items of the Apathy/Indifference subscale were designated by consensus as: A) affective = lacking in emotions, B) behavioral = inactive, chores abandoned or C) cognitive = no interest in others' activities. Proportions of correlated non-apathy NPI items were calculated and displayed using Chernoff faces to facilitate comparison of apathy domains and dementia diagnoses. Several neurology specialty clinics contributed to our dataset of 92 participants with FTD and 457 with DAT. Apathy was more prevalent in FTD than DAT, but when present, the specific apathy symptoms in both dementias were rarely restricted to one of the three domains of apathy. Dysphoria concurrent with apathy was unique to the DAT group and negatively correlated in FTD. Participants with affective apathy more frequently co-presented with an orbitofrontosubcortical syndrome in FTD (impulsivity and compulsions). Affective apathy also co-presented with uncooperative agitation, anger, and physical agitation in both dementias. Apathy is common in FTD and in DAT, although it is more common in FTD. When present, it usually involves changes in affect, behavior, and cognition. It is associated with behaviors that have previously been shown to impact on patient safety, independence and quality of life.
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影响因子：
6.7
作者：
Chow, Tiffany W
通讯作者：
Chow, Tiffany W
影响因子：
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