The genetic and environmental influences of event-related gamma oscillations on bipolar disorder.
The genetic and environmental influences of event-related gamma oscillations on bipolar disorder.
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DOI：
10.1111/j.1399-5618.2011.00925.x
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发表时间：
2011-05
影响因子：
5.4
通讯作者：
Rijsdijk F
中科院分区：
文献类型：
--
作者：
Hall MH;Spencer KM;Schulze K;McDonald C;Kalidindi S;Kravariti E;Kane F;Murray RM;Bramon E;Sham P;Rijsdijk F
伽马振荡在神经信息编码中起着重要的作用。双相情感障碍（BPD）诱发γ波带反应（GBR）的电生理学研究数量有限。目前还不清楚GBR缺陷（如果存在）是否是BPD的潜在内在表型，因为对GBR的遗传性知之甚少。本研究旨在探讨是否GBR来自两个听觉任务，oddball任务和双击范式，是潜在的BPD内表型。本研究共纳入308例受试者：198例健康对照，59例BPD患者（22例单卵BPD双胞胎和37例来自31个家庭的BPD患者）和51例未受影响的亲属。使用Morlet小波变换计算诱发的伽马响应。结构方程模型，以获得遗传（遗传力）和环境估计在每个GBR变量和他们的（遗传）与BPD重叠。在oddball任务中，GBR对标准刺激的遗传度估计为0.51，对目标刺激的遗传度估计为0.35。然而，在BPD患者或其未受影响的亲属中，两种反应类型均未受损。在双击范式中，GBR对S1刺激的遗传度估计值为0.54，对S2刺激的遗传度估计值为0.50。BPD患者对S1刺激的γ功率和抑制降低，但其未受影响的亲属没有。诱发GBR是可遗传的特征。然而，在临床上未受影响的亲属中未观察到GBR缺陷，也未观察到与BPD相关。γ反应似乎不符合BPD内表型的标准。
Gamma oscillations have been proposed to play an important role in neural information coding. There have been a limited number of electrophysiology studies in evoked gamma band responses (GBRs) in bipolar disorder (BPD). It is also unclear whether GBR deficits, if present, are potential endophenotypes for BPD as little is known about the heritability of GBRs. The present study aimed to examine whether GBRs derived from two auditory tasks, the oddball task and the dual-click paradigm, are potential BPD endophenotypes. A total of 308 subjects were included in this study: 198 healthy controls, 59 BPD patients (22 monozygotic BPD twins and 37 BPD patients from 31 families), and 51 unaffected relatives. The evoked gamma responses were calculated using a Morlet wavelet transformation. Structural equation modelling was applied to obtain the genetic (heritability) and environment estimates in each GBR variable and their (genetic) overlap with BPD. The heritability estimates of GBR to standard stimuli were 0.51 and 0.35 to target stimuli in the oddball task. However, neither response type was impaired in BPD patients or their unaffected relatives. The heritability estimates of GBR to S1 stimuli were 0.54 and 0.50 to S2 stimuli in the dual-click paradigm. BPD patients had reduced gamma power and suppression to S1 stimuli but their unaffected relatives did not. Evoked GBRs are heritable traits. However, GBR deficits are not observed in clinically unaffected relatives nor associated with BPD. Gamma responses do not appear to satisfy criteria for being BPD endophenotypes.
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影响因子：
17.7
作者：
Clark, L;Sarna, A;Goodwin, GM
通讯作者：
Goodwin, GM
影响因子：
10.6
作者：
Frangou, S;Haldane, M;Kumari, V
通讯作者：
Kumari, V
影响因子：
2
作者：
Clementz, BA;Blumenfeld, LD
通讯作者：
Blumenfeld, LD
DOI：
10.1002/ajmg.b.30653
发表时间：
2008-07-05
影响因子：
2.8
作者：
Hall, Mei-Hua;Schulze, Katja;Rijsdijk, Fruehling
通讯作者：
Rijsdijk, Fruehling
影响因子：
5.4
作者：
Carroll, Christine A.;Kieffaber, Paul D.;Hetrick, William P.
通讯作者：
Hetrick, William P.