Variability and predictors of serum perfluoroalkyl substance concentrations during pregnancy and early childhood.
Variability and predictors of serum perfluoroalkyl substance concentrations during pregnancy and early childhood.
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DOI：
10.1016/j.envres.2018.04.033
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发表时间：
2018-08
影响因子：
8.3
通讯作者：
Braun JM
中科院分区：
文献类型：
--
作者：
Kingsley SL;Eliot MN;Kelsey KT;Calafat AM;Ehrlich S;Lanphear BP;Chen A;Braun JM
多氟烷基和全氟烷基物质（PFAS）是一种普遍存在的持久性环境污染物，暴露于这种物质可能与不良健康结果有关，但儿童时期暴露的纵向数据评估模式和预测因素有限。在2003-2006年的前瞻性队列研究中，我们对367对母亲和孩子的血清中8种不同PFAS的浓度进行了量化。一般来说，儿童PFAS浓度中位数从出生到3岁增加，然后在8岁时下降。妊娠期母体血清PFAS浓度与脐带血清浓度呈显著正相关（0.76<r<0.94），与儿童期浓度呈弱相关（0.12<r<0.30）。几个社会人口因素与母体PFAS浓度相关，包括收入、种族和均等。在儿童中，血清PFAS浓度与母亲的分娩年龄、种族、胎次和儿童年龄有关。母乳喂养时间与儿童3岁和8岁时PFAS浓度呈正相关。此外，在8岁时，使用抗污剂与较高的全氟辛酸和全氟己烷磺酸浓度有关。血清PFAS浓度在儿童早期较高，这是一个潜在的敏感发育时期，在母乳喂养的儿童中最高。
Exposure to poly- and perfluoroalkyl substances (PFAS), ubiquitous and persistent environmental contaminants, could be associated with adverse health outcomes, but there are limited longitudinal data assessing patterns and predictors of exposure during childhood. We quantified concentrations of eight different PFAS in sera collected from women during pregnancy and children at delivery and ages 3 and 8 years in 367 mother-child pairs enrolled in a prospective cohort from 2003–2006. In general, median childhood PFAS concentrations increased from birth to age 3 and then decreased by age 8. Maternal serum PFAS concentrations during pregnancy were strongly correlated with cord serum concentrations (0.76<r<0.94), but were weakly correlated with childhood concentrations (0.12<r<0.30). Several sociodemographic factors were associated with maternal PFAS concentrations, including income, race, and parity. In children, serum PFAS concentrations were associated with maternal age at delivery, race, parity, and child age. Breastfeeding duration was positively associated with childhood PFAS concentrations at ages 3 and 8 years. In addition, stain repellant use was associated with higher perfluorooctanoic acid and perfluorohexane sulfonic acid concentrations at age 8 years. Serum PFAS concentrations are higher during early childhood, a potentially sensitive period of development, and were highest among breastfed children.
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DOI：
10.1038/jes.2009.73
发表时间：
2011-03-01
影响因子：
4.5
作者：
Egeghy, Peter P.;Lorber, Matthew
通讯作者：
Lorber, Matthew
影响因子：
10.4
作者：
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DOI：
10.1002/oby.21258
发表时间：
2016-01
期刊：
Obesity (Silver Spring, Md.)
影响因子：
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作者：
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通讯作者：
Lanphear BP
怀孕挪威妇女的全氟烷基物质血浆浓度的决定因素。
影响因子：
11.8
作者：
Brantsaeter, A. L.;Whitworth, K. W.;Ydersbond, T. A.;Haug, L. S.;Haugen, M.;Knutsen, H. K.;Thomsen, C.;Meltzer, H. M.;Becher, G.;Sabaredzovic, A.;Hoppin, J. A.;Eggesbo, M.;Longnecker, M. P.
通讯作者：
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影响因子：
6.3
作者：
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通讯作者：
Olsen, Jorn