Effects of Alcohol Withdrawal on Sleep Macroarchitecture and Microarchitecture in Female and Male Rats.
Effects of Alcohol Withdrawal on Sleep Macroarchitecture and Microarchitecture in Female and Male Rats.
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DOI：
10.3389/fnins.2022.838486
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发表时间：
2022
影响因子：
4.3
通讯作者：
Schmeichel, Brooke E.
中科院分区：
文献类型：
--
作者：
Jones, Marissa R.;Brandner, Adam J.;Vendruscolo, Leandro F.;Vendruscolo, Janaina C. M.;Koob, George F.;Schmeichel, Brooke E.
关键词：
与非AUD个体相比，患有酒精使用障碍（AUD）的人睡眠中断的患病率更高，特别是在酒精戒断期间。尽管女性通常有更高的睡眠障碍风险，但很少有研究调查长期酒精暴露后睡眠中断的性别差异。本研究探讨了睡眠的宏观架构（睡眠或清醒和睡眠潜伏期所花费的时间）和微架构（回合率和持续时间和睡眠纺锤体表征）之前，酒精蒸汽暴露（基线），在急性戒断，并通过长期禁欲的女性和男性大鼠。在急性戒断期间，女性和男性的快速眼动（REM）睡眠时间减少，在长期戒断期间恢复到基线水平。REM睡眠开始潜伏期下降，在长期禁欲的女性。此外，在整个REM睡眠回合率中观察到性别差异。尽管非REM睡眠时间或非REM睡眠回合率或持续时间没有变化，但女性和男性在急性戒断期间的非REM睡眠内纺锤波频率均增加。最后，在雌性和雄性动物中，急性戒断期间的觉醒时间和发作持续时间均增加。结果表明，在长期酒精暴露后，特别是在急性戒断期间，睡眠的宏观和微观结构变化，这表明需要对AUD患者戒断期间的睡眠障碍进行治疗干预。此外，在REM睡眠中观察到性别差异，强调了在未来酒精相关睡眠研究中包括两性的重要性。
The prevalence of sleep disruptions is higher among people with alcohol use disorder (AUD), particularly during alcohol withdrawal, compared to non-AUD individuals. Although women generally have a higher risk of developing sleep disorders, few studies have investigated sex differences in sleep disruptions following chronic alcohol exposure. The present study examined sleep macroarchitecture (time spent asleep or awake and sleep onset latency) and microarchitecture (bout rate and duration and sleep spindle characterization) prior to alcohol vapor exposure (baseline), during acute withdrawal, and through protracted abstinence in female and male rats. Females and males showed reduced time in rapid eye movement (REM) sleep during acute withdrawal, which returned to baseline levels during protracted abstinence. REM sleep onset latency was decreased during protracted abstinence in females only. Furthermore, there was a sex difference observed in overall REM sleep bout rate. Although there were no changes in non-REM sleep time, or to non-REM sleep bout rate or duration, there was an increase in non-REM sleep intra-spindle frequency during acute withdrawal in both females and males. Finally, there was increased wakefulness time and bout duration during acute withdrawal in both females and males. The results demonstrate both macroarchitectural and microarchitectural changes in sleep following chronic alcohol exposure, particularly during acute withdrawal, suggesting the need for therapeutic interventions for sleep disturbances during withdrawal in individuals with AUD. Furthermore, sex differences were observed in REM sleep, highlighting the importance of including both sexes in future alcohol-related sleep studies.
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DOI：
10.1111/acer.13584
发表时间：
2018-03
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Huitron-Resendiz S;Nadav T;Krause S;Cates-Gatto C;Polis I;Roberts AJ
通讯作者：
Roberts AJ
影响因子：
3.2
作者：
Chan, Julia K. M.;Trinder, John;Nicholas, Christian L.
通讯作者：
Nicholas, Christian L.
DOI：
10.1111/j.1530-0277.2010.01417.x
发表时间：
2011-05
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Arnedt JT;Rohsenow DJ;Almeida AB;Hunt SK;Gokhale M;Gottlieb DJ;Howland J
通讯作者：
Howland J
DOI：
10.1080/10253890.2021.1879788
发表时间：
2021-01-29
影响因子：
2.3
作者：
Gargiulo, Andrew T.;Jasodanand, Varuna;Grafe, Laura A.
通讯作者：
Grafe, Laura A.
影响因子：
3.2
作者：
Chan, Julia K. M.;Trinder, John;Nicholas, Christian L.
通讯作者：
Nicholas, Christian L.