Pyramidal cells in prefrontal cortex of primates: marked differences in neuronal structure among species.
Pyramidal cells in prefrontal cortex of primates: marked differences in neuronal structure among species.
复制标题
灵长类动物前额叶皮层中的锥体细胞：物种之间神经元结构的明显差异。
DOI：
10.3389/fnana.2011.00002
复制
发表时间：
2011
影响因子：
2.9
通讯作者：
Defelipe J
中科院分区：
文献类型：
--
作者：
Elston GN;Benavides-Piccione R;Elston A;Manger PR;Defelipe J
锥体细胞是大脑皮层中最普遍存在的神经元，其特征在于在不同的皮层区域中具有明显不同的树突结构。复杂的锥体细胞表型颗粒前额叶皮层（gPFC）的高等灵长类动物赋予特定的生物物理特性和模式的连接，这不同于其他皮质区域。然而，在gPFC中，数据仅从选定的少数皮质区域中采样。人类和猕猴等物种的gPFC包括10个以上的皮质区。锥体细胞结构在这些皮层区域中的变化程度仍然未知。在这里，我们进行了调查的锥体细胞的背外侧，内侧和眶gPFC的猕猴类灵长类动物。我们发现这些区域内和之间的锥体细胞结构显着的异质性。此外，神经元复杂性的梯度趋势在物种之间存在差异。由于神经元的结构决定了它们的计算能力、记忆存储能力和连通性，因此我们认为这些锥体细胞表型的特化是灵长类动物物种特异性执行皮层功能的重要决定因素。
The most ubiquitous neuron in the cerebral cortex, the pyramidal cell, is characterized by markedly different dendritic structure among different cortical areas. The complex pyramidal cell phenotype in granular prefrontal cortex (gPFC) of higher primates endows specific biophysical properties and patterns of connectivity, which differ from those in other cortical regions. However, within the gPFC, data have been sampled from only a select few cortical areas. The gPFC of species such as human and macaque monkey includes more than 10 cortical areas. It remains unknown as to what degree pyramidal cell structure may vary among these cortical areas. Here we undertook a survey of pyramidal cells in the dorsolateral, medial, and orbital gPFC of cercopithecid primates. We found marked heterogeneity in pyramidal cell structure within and between these regions. Moreover, trends for gradients in neuronal complexity varied among species. As the structure of neurons determines their computational abilities, memory storage capacity and connectivity, we propose that these specializations in the pyramidal cell phenotype are an important determinant of species-specific executive cortical functions in primates.
登录
查看更多内容
影响因子：
2.4
作者：
Barbas H;Hilgetag CC;Saha S;Dermon CR;Suski JL
通讯作者：
Suski JL
影响因子：
2.4
作者：
Benavides-Piccione, Ruth;DeFelipe, Javier
通讯作者：
DeFelipe, Javier
影响因子：
2.5
作者：
DELIMA, AD;VOIGT, T;MORRISON, JH
通讯作者：
MORRISON, JH
DOI：
10.1002/ar.a.20207
发表时间：
2005-07-01
期刊：
ANATOMICAL RECORD PART A-DISCOVERIES IN MOLECULAR CELLULAR AND EVOLUTIONARY BIOLOGY
影响因子：
--
作者：
Collins, CE;Lyon, DC;Kaas, JH
通讯作者：
Kaas, JH
影响因子：
2.5
作者：
Blazquez-Llorca, Lidia;Garcia-Marin, Virginia;DeFelipe, Javier
通讯作者：
DeFelipe, Javier