White matter changes in healthy adolescents at familial risk for unipolar depression: a diffusion tensor imaging study.
White matter changes in healthy adolescents at familial risk for unipolar depression: a diffusion tensor imaging study.
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DOI：
10.1038/npp.2010.199
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发表时间：
2011-02
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影响因子：
--
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中科院分区：
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--
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据报道，一些皮质和皮质下回路的白质完整性改变与单相重度抑郁症有关。目前尚不清楚这些白质变化是否先于疾病发作。 13 名没有精神疾病个人或家族史的青少年志愿者（对照组）和 18 名没有包括抑郁症在内的精神疾病个人史，但由于父母抑郁症而有患单相抑郁症高风险的青少年志愿者（高危青少年）接受了弥散张量成像研究。使用基于束的自动空间统计（TBSS）方法，即全脑逐个体素分析，来分析扫描结果。还计算了每个区域的群体平均扩散参数值。与对照组相比，单相抑郁高危青少年的左侧扣带回、胼胝体压部、上纵束、钩突和下额枕束的各向异性分数（FA）值较低。具有单相抑郁家族风险的健康青少年的白质完整性改变表明，它可能是该疾病的脆弱性标志。
Alterations in white matter integrity of several cortical and sub-cortical circuits have been reported in relation to unipolar major depressive disorder. It is not clear whether these white matter changes precede the onset of illness. Thirteen adolescent volunteers with no personal or family history of a psychiatric disorder (controls) and 18 adolescent volunteers with no personal history of a psychiatric illness including depression, but who were at high risk for developing unipolar depression by virtue of parental depression (high-risk youth), underwent diffusion tensor imaging studies. An automated tract-based spatial statistics (TBSS) method, a whole-brain voxel-by-voxel analysis, was used to analyze the scans. Population average diffusion parameter values also were calculated for each tract. Adolescents at high risk for unipolar depression had lower fractional anisotropy (FA) values in the left cingulum, splenium of the corpus callosum, superior longitudinal fasciculi, uncinate and inferior fronto-occipital fasciculi than controls. Altered white matter integrity in healthy adolescents at familial risk for unipolar depression suggests that it might serve as a vulnerability marker for the illness.
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DOI：
10.1073/pnas.0402680101
发表时间：
2004-05-25
影响因子：
11.1
作者：
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DOI：
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影响因子：
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