Objectively measured sleep duration and hyperglycemia in pregnancy.

Objectively measured sleep duration and hyperglycemia in pregnancy.
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DOI:
10.1016/j.sleep.2013.07.018
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发表时间:
2014-01
期刊:
影响因子:
4.8
通讯作者:
Foster, Gary D.
Foster, Gary D.
中科院分区:
医学2区
文献类型:
--
作者:
Herring, Sharon J.;Nelson, Deborah B.;Pien, Grace W.;Homko, Carol;Goetzl, Laura M.;Davey, Adam;Foster, Gary D.

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我们的主要目的是评估客观测量的夜间睡眠时间对妊娠糖耐量的影响。此外,我们还检查了客观测量的日间睡眠时间和午睡频率与母亲血糖控制的关系。63名城市低收入孕妇在怀孕中期平均全天佩戴腕部活动记录仪,然后使用1小时口服葡萄糖耐量试验(OGTT)筛查高血糖。分析夜间和日间睡眠时间与1h OGTT值的相关性。多变量Logistic回归用于评估睡眠参数和高血糖之间的独立相关性,高血糖定义为1hOGTT值≥130 mg/dL。夜间平均睡眠时间为6.9±0.9h,与1h OGTT值呈负相关(r=−0.2 8,p=0.0 3)。即使在控制了年龄和体重指数后,夜间睡眠时间较短也与高血糖有关(调整后的OR:0.2;95%CI:0.1,0.8)。白天睡眠时间和午睡频率与1小时OGTT值或高血糖没有关联。使用对母亲睡眠时间的客观测量,我们发现夜间睡眠时间较短的女性患妊娠期高血糖的风险增加。需要更大规模的前瞻性研究来证实我们白天睡眠的负面发现。
Our primary purpose was to assess the impact of objectively-measured nighttime sleep duration on gestational glucose tolerance. We additionally examined associations of objectively-measured daytime sleep duration and nap frequency on maternal glycemic control. 63 urban, low-income, pregnant women wore wrist actigraphs for an average of 6 full days in mid-pregnancy prior to screening for hyperglycemia using the 1-hour oral glucose tolerance test (OGTT). Correlations of nighttime and daytime sleep durations with 1-hour OGTT values were analyzed. Multivariable logistic regression was used to evaluate independent associations between sleep parameters and hyperglycemia, defined as 1-hour OGTT values ≥ 130 mg/dL. Mean nighttime sleep duration was 6.9 ± 0.9 hours which was inversely correlated with 1-hour OGTT values (r = −0.28, p = 0.03). Shorter nighttime sleep was associated with hyperglycemia, even after controlling for age and body mass index (adjusted OR: 0.2; 95% CI: 0.1, 0.8). There were no associations of daytime sleep duration and nap frequency with 1-hour OGTT values or hyperglycemia. Using objective measures of maternal sleep time, we found that women with shorter nighttime sleep durations had an increased risk of gestational hyperglycemia. Larger prospective studies are needed to confirm our negative daytime sleep findings.
睡眠障碍及其与妊娠葡萄糖耐受性的关系。
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