Viral etiology and seasonality of influenza-like illness in Gabon, March 2010 to June 2011.
Viral etiology and seasonality of influenza-like illness in Gabon, March 2010 to June 2011.
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DOI：
10.1186/1471-2334-14-373
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发表时间：
2014-07-07
影响因子：
3.7
通讯作者：
Leroy EM
中科院分区：
文献类型：
--
作者：
Lekana-Douki SE;Nkoghe D;Drosten C;Ngoungou EB;Drexler JF;Leroy EM
中非的流感样疾病监测工作最近才开始，因此关于流感病毒和其他呼吸道病毒传播的数据很少。在中非国家加蓬，我们在四个主要城镇建立了一个监测网络，以分析2010年3月至2011年6月期间访问卫生中心的患者中的ILI病例，并确定病毒病原学。将鼻拭子送至Franceville国际医学研究中心进行分析，在该中心，根据以下配对，采用多重实时逆转录聚合酶链反应对所有病原体进行17种呼吸道病毒筛查：腺病毒/副流感病毒4，呼吸道合胞病毒/人偏肺病毒，副流感病毒1/副流感病毒2，大流行性流感病毒A/季节性流感病毒A（H1N1，H3 N2）/季节性流感病毒B、人冠状病毒229 E/OC 43、人冠状病毒NL 63/HKU 1、鼻病毒/人双埃柯病毒和肠道病毒/副流感病毒3。我们共分析了1041份标本，其中639份（61%）至少对一种病毒呈阳性。四分之三的病人是五岁以下的儿童。因此，我们将重点放在这个年龄组，其中68.1%的患者至少对一种病毒呈阳性。最常见的病毒是腺病毒（17.5%），其次是副流感病毒（PIV）1-4（16.8%）、肠道病毒（EV）（14.7%）、呼吸道合胞病毒（RSV）（13.5%）和流感病毒（11.9%）。某些病毒的流行受地理和季节变化的影响。三分之一的阳性样本含有一种以上的病毒。与世界上大多数研究一样，病毒PIV、EV、RSV、流感病毒、HRV在加蓬5岁以下儿童中占主导地位。在我们的研究中，腺病毒是一个例外。然而，腺病毒可以在无症状的人中检测到。这些发现使人们更好地了解了在加蓬与ILI有关的病毒的传播和季节性。
Surveillance of influenza-like illness (ILI) in Central Africa began only recently, and few data are therefore available on the circulation of influenza virus and other respiratory viruses. In Gabon, a Central African country, we established a surveillance network in four major towns in order to analyze cases of ILI among patients who visited health centers between March 2010 and June 2011, and to determine the viral etiology. Nasal swabs were sent for analysis to the Centre International de Recherches Médicales de Franceville, where they were screened for 17 respiratory viruses in a multiplex real-time reverse transcription polymerase chain reaction for all pathogens according the following pairs: adenovirus/parainfluenza virus 4, respiratory syncytial virus/human metapneumovirus, parainfluenza virus 1/parainfluenza virus 2, pandemic influenza virus A/seasonal influenza virus A (H1N1, H3N2)/seasonal influenza virus B, human coronaviruses 229E/OC43, human coronaviruses NL63/HKU1, rhinovirus/human parechovirus, and enterovirus/parainfluenza virus 3. We analyzed a total of 1041 specimens, of which 639 (61%) were positive for at least one virus. Three-quarters of the patients were children under five years old. We therefore focused on this age group, in which 68.1% of patients were positive for at least one virus. The most common viruses were adenoviruses (17.5%), followed by parainfluenza viruses (PIVs) 1–4 (16.8%), enteroviruses (EV) (14.7%), respiratory syncytial virus (RSV) (13.5%), and influenza virus (11.9%). The prevalence of some viruses was subject to geographic and seasonal variations. One-third of positive samples contained more than one virus. Like most studies in the world, the virus PIVs, EV, RSV, Influenza virus, HRV were predominant among children under five years old in Gabon. An exception is made for adenoviruses which have a high prevalence in our study. However adenoviruses can be detected in asymptomatic persons. These finding gave a better knowledge of the circulation and the seasonality of the viruses involved in ILI in Gabon.
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