Early sensory contributions to contextual encoding deficits in schizophrenia.
Early sensory contributions to contextual encoding deficits in schizophrenia.
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DOI：
10.1001/archgenpsychiatry.2011.17
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发表时间：
2011-07
影响因子：
--
通讯作者：
Javitt, Daniel C.
中科院分区：
文献类型：
--
作者：
Dias, Elisa C.;Butler, Pamela D.;Hoptman, Matthew J.;Javitt, Daniel C.
视觉连续操作任务(AX-CPT)的AX版本被广泛用于研究精神分裂症患者的视觉工作记忆功能障碍。事件相关电位(ERP)提供了一个客观的脑功能指标，可用于评估精神分裂症患者认知损害的脑基础。目的：评估精神分裂症患者视觉工作记忆功能障碍与早期视觉加工障碍之间的关系。慢性治疗环境下的组间设计，30名精神分裂症患者和17名健康对照受试者。三个版本的AX-CPT被用来测试在不同挑战情境下的表现和潜在的神经活动。对比敏感度测量来自大多数受试者。行为表现使用d‘-语境分数进行评估。使用感觉(C_1，P_1，N_1)和认知(N_2，CNV)事件相关电位成分来评估与刺激和任务相关的皮层激活对线索和探测刺激的完整性。用对比敏感度评估早期巨细胞/小细胞功能。使用线性回归和通径分析来评估生理和行为参数之间的关系。患者表现出早期感觉(P1，N1)和晚期认知(N2，CNV)事件相关电位成分的波幅降低。提示刺激的感觉(N1)和认知(N2)成分的缺陷独立地导致行为表现受损。此外，感觉缺陷预示着认知事件相关电位生成受损。最后，表现缺陷与对低空间频率刺激而非高空间频率刺激的对比敏感度受损有关。精神分裂症的工作记忆缺陷越来越多地被归因于刺激编码的障碍，而不是记忆保持的失败。本研究为假说的编码提供了客观的生理学支持。此外，感觉处理的缺陷显著地损害了工作记忆的表现，这与精神分裂症的一般神经化学模型一致。
The “AX”-version of the visual continuous performance task (AX-CPT) is widely used for investigating visual working memory dysfunction in schizophrenia. Event-related potentials (ERP) provide an objective index of brain function, and can be used to evaluate brain substrates underlying impaired cognition in schizophrenia. To assess mechanisms underlying visual working memory dysfunction in schizophrenia relative to impairment of early visual processing. Between-group design in a chronic treatment setting, with 30 individuals with schizophrenia and 17 healthy comparison subjects. Three versions of AX-CPT, with parametric variations of the proportions of trial types, were used to test performance and underlying neural activity under differential challenge situations. Contrast sensitivity measures were obtained from the majority of subjects. Behavioral performance was assessed using d’-context scores. Integrity of stimulus- and task-related cortical activation to both cue and probe stimuli was assessed using sensory (C1, P1, N1) and cognitive (N2, CNV) ERP components. Early magnocellular/parvocellular function was assessed using contrast sensitivity. Linear regression and path analyses were used to assess relations between physiological and behavioral parameters. Patients showed reduced amplitude of both early sensory (P1, N1) and later cognitive (N2, CNV) ERP components. Deficits in sensory (N1) and cognitive (N2) components to cue stimuli contributed independently to impaired behavioral performance. In addition, sensory deficits predicted impaired cognitive ERP generation. Finally, deficits in performance correlated with impairments in contrast sensitivity to low, but not high, spatial frequency stimuli. Working memory deficits in schizophrenia have increasingly been attributed to impairments in stimulus encoding, rather than to failures in memory retention. The present study provides objective physiological support for encoding hypotheses. Further, deficits in sensory processing contribute significantly to impaired working memory performance, consistent with generalized neurochemical models of schizophrenia.
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影响因子：
5.3
作者：
Green, Michael F.
通讯作者：
Green, Michael F.
影响因子：
--
作者：
Gold, James M.;Hahn, Britta;Zhang, Wei Wei;Robinson, Benjamin M.;Kappenman, Emily S.;Beck, Valerie M.;Luck, Steven J.
通讯作者：
Luck, Steven J.
影响因子：
5.4
作者：
COHEN, JD;SERVANSCHREIBER, D
通讯作者：
SERVANSCHREIBER, D
影响因子：
10.6
作者：
Braver, TS;Barch, DM;Cohen, JD
通讯作者：
Cohen, JD
影响因子：
17.7
作者：
Butler, Pamela D.;Hoptman, Matthew J.;Lim, Kelvin O.
通讯作者：
Lim, Kelvin O.