Absence of Tangentially Migrating Glutamatergic Neurons in the Developing Avian Brain.
Absence of Tangentially Migrating Glutamatergic Neurons in the Developing Avian Brain.
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DOI：
10.1016/j.celrep.2017.12.032
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发表时间：
2018-01-02
期刊：
影响因子：
8.8
通讯作者：
Molnár Z
中科院分区：
文献类型：
--
作者：
García-Moreno F;Anderton E;Jankowska M;Begbie J;Encinas JM;Irimia M;Molnár Z
在哺乳动物胚胎发生过程中，几个神经元群体协调新皮层的发育。这些包括丘脑能亚板，Cajal-Retzius，腹侧苍白球衍生的人口，协调皮质布线，迁移和增殖，分别。这些短暂的人口主要来自其他非皮质苍白球来源迁移到背侧苍白球。这些迁移到背颚的行为是在狐猴中保守的，还是哺乳动物特有的？使用卵内电穿孔，我们追踪了定义的鸡端脑祖细胞的整个谱系。我们发现，在哺乳动物中产生切向迁移神经元的几个苍白层来源只在鸟类大脑中产生径向迁移神经元。此外，异位表达的VP特异性哺乳动物Dbx 1在鸟类大脑中改变神经发生，但没有转换成哺乳动物样的切线运动的迁移。总之，这些数据表明，切向细胞的贡献，aplamatergic神经元起源于外的背腭和苍白球Dbx 1的表达可能是哺乳动物新皮层在进化过程中产生的基础。缺乏切向迁移的Cajal-Retzius和subplate细胞在鸡没有内pallial切向迁移有助于在鸡的背侧腭哺乳动物Dbx 1促进在鸡腹侧腭的分化分裂独特的切向迁移可能发挥了重要作用，在皮质的进化新皮质的形成至关重要地依赖于早期切向到达的几个短暂的神经元群体。加西亚-莫雷诺等人发现这些神经元迁移在小鸡发育中的大脑中是不存在的。哺乳动物的独特性，这些发展中的迁移表明，这些细胞在新皮层的进化起源中发挥着至关重要的作用。
Several neuronal populations orchestrate neocortical development during mammalian embryogenesis. These include the glutamatergic subplate-, Cajal-Retzius-, and ventral pallium-derived populations, which coordinate cortical wiring, migration, and proliferation, respectively. These transient populations are primarily derived from other non-cortical pallial sources that migrate to the dorsal pallium. Are these migrations to the dorsal pallium conserved in amniotes or are they specific to mammals? Using in ovo electroporation, we traced the entire lineage of defined chick telencephalic progenitors. We found that several pallial sources that produce tangential migratory neurons in mammals only produced radially migrating neurons in the avian brain. Moreover, ectopic expression of VP-specific mammalian Dbx1 in avian brains altered neurogenesis but did not convert the migration into a mammal-like tangential movement. Together, these data indicate that tangential cellular contributions of glutamatergic neurons originate from outside the dorsal pallium and that pallial Dbx1 expression may underlie the generation of the mammalian neocortex during evolution. Lack of tangential migration of Cajal-Retzius and subplate cells in chick No intra-pallial tangential migrations contribute to the dorsal pallium in chick Mammalian Dbx1 promotes differentiative divisions in chick ventral pallium Unique tangential migrations could have played a major role in cortical evolution Neocortical formation crucially depends on the early tangential arrival of several transient glutamatergic neuronal populations. García-Moreno et al. find that these neuronal migrations are absent in the developing brain of chicks. The mammalian uniqueness of these developing migrations suggests a crucial role of these cells in the evolutionary origin of the neocortex.
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